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chaperone-mediated autophagy

Known as: CMA 
The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process… Expand
National Institutes of Health

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Highly Cited
2013
Highly Cited
2013
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be… Expand
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Highly Cited
2011
Highly Cited
2011
Most tumor cells take up more glucose than normal cells but metabolize glucose via glycolysis even in the presence of normal… Expand
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Highly Cited
2008
Highly Cited
2008
Altered degradation of alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of Parkinson disease (PD). We have… Expand
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Highly Cited
2008
Highly Cited
2008
α-Synuclein (ASYN) is crucial in Parkinson disease (PD) pathogenesis. Increased levels of wild type (WT) ASYN expression are… Expand
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Highly Cited
2008
Highly Cited
2008
Chaperone-mediated autophagy (CMA) is the only type of autophagy in mammalian cells able to selectively degrade cytosolic… Expand
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Highly Cited
2008
Highly Cited
2008
Chaperone-mediated autophagy (CMA), a selective mechanism for degradation of cytosolic proteins in lysosomes, contributes to the… Expand
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Highly Cited
2008
Highly Cited
2008
ABSTRACT Chaperone-mediated autophagy (CMA) is a selective type of autophagy by which specific cytosolic proteins are sent to… Expand
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Review
2006
Review
2006
Different mechanisms target intracellular components for their degradation into lysosomes through what is known as autophagy. In… Expand
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Highly Cited
2004
Highly Cited
2004
Oxidatively damaged proteins accumulate with age in almost all cell types and tissues. The activity of chaperone-mediated… Expand
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Highly Cited
2003
Highly Cited
2003
This paper presents a novel evolutionary optimization strategy based on the derandomized evolution strategy with covariance… Expand
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