chaperone-mediated autophagy

Known as: CMA 
The autophagy process which begins when chaperones and co-chaperones recognize a KFERQ-related motif and unfold the substrate protein. The process… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1965-2017
010020019652017

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Review
2016
Review
2016
Proteostasis refers to the regulation of the cellular concentration, folding, interactions and localization of each of the… (More)
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Highly Cited
2013
Highly Cited
2013
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE To investigate chaperone-mediated autophagy in the pathogenesis of Parkinson disease (PD). DESIGN Postmortem… (More)
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Highly Cited
2009
Highly Cited
2009
Chaperone-mediated autophagy controls the degradation of selective cytosolic proteins and may protect neurons against… (More)
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Highly Cited
2008
Highly Cited
2008
Altered degradation of alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of Parkinson disease (PD). We have… (More)
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Highly Cited
2008
Highly Cited
2008
Alpha-synuclein (ASYN) is crucial in Parkinson disease (PD) pathogenesis. Increased levels of wild type (WT) ASYN expression are… (More)
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Highly Cited
2008
Highly Cited
2008
Chaperone-mediated autophagy (CMA) is a selective type of autophagy by which specific cytosolic proteins are sent to lysosomes… (More)
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Highly Cited
2006
Highly Cited
2006
Chaperone-mediated autophagy (CMA) is a selective pathway for the degradation of cytosolic proteins in lysosomes. CMA declines… (More)
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Highly Cited
2004
Highly Cited
2004
Aberrant alpha-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the… (More)
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Highly Cited
2000
Highly Cited
2000
Intracellular protein degradation rates decrease with age in many tissues and organs. In cultured cells, chaperone-mediated… (More)
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