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chalcone oxide

 
National Institutes of Health

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chalcone epoxide

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2016
2016
Chiral Cobalt(III) Complexes as Bifunctional Brønsted Acid-Lewis Base Catalysts for the Preparation of Cyclic Organic Carbonates.
Stereochemically inert cationic cobalt(III) complexes were shown to be one-component catalysts for the synthesis of cyclic… Expand
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2012
2012
DESIGN, ADMET AND DOCKING STUDIES ON SOME NOVEL CHALCONE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORS
Drug discovery is a lengthy and costly process which aims at bringing in a novel therapeutic molecule for the treatment of… Expand
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2011
2011
Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl… Expand
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Highly Cited
2000
Highly Cited
2000
Biochemical Evidence for the Involvement of Tyrosine in Epoxide Activation during the Catalytic Cycle of Epoxide Hydrolase*
Epoxide hydrolases (EH) catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols. The crystal structure… Expand
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1999
1999
Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver.
Soluble epoxide hydrolase (sEH) is a ubiquitous mammalian enzyme for which liver and kidney are reported to have the highest… Expand
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1998
1998
Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives.
A series of substituted chalcone oxides (1,3-diphenyl-2-oxiranyl propanones) and structural analogs was synthesized to… Expand
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1992
1992
Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes.
The effect of modulating epoxide metabolism by inhibiting microsomal and cytosolic epoxide hydrolases and depleting glutathione… Expand
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1986
1986
Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice.
An affinity purification procedure was developed for the cytosolic epoxide hydrolase based upon the selective binding of the… Expand
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1982
1982
Chalcone oxides--potent selective inhibitors of cytosolic epoxide hydrolase.
The systematic screening of over 150 compounds for inhibitory activity on mammalian cytosolic epoxide hydrolase led to… Expand
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