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chalcone oxide

National Institutes of Health

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chalcone epoxide

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Highly Cited
2016
Highly Cited
2016
Chiral Cobalt(III) Complexes as Bifunctional Brønsted Acid-Lewis Base Catalysts for the Preparation of Cyclic Organic Carbonates.
Stereochemically inert cationic cobalt(III) complexes were shown to be one-component catalysts for the synthesis of cyclic… 
2012
2012
DESIGN, ADMET AND DOCKING STUDIES ON SOME NOVEL CHALCONE DERIVATIVES AS SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORS
Drug discovery is a lengthy and costly process which aims at bringing in a novel therapeutic molecule for the treatment of… 
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2011
2011
Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl… 
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Highly Cited
2000
Highly Cited
2000
Biochemical Evidence for the Involvement of Tyrosine in Epoxide Activation during the Catalytic Cycle of Epoxide Hydrolase*
Epoxide hydrolases (EH) catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols. The crystal structure… 
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1999
1999
Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver.
Soluble epoxide hydrolase (sEH) is a ubiquitous mammalian enzyme for which liver and kidney are reported to have the highest… 
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Highly Cited
1998
Highly Cited
1998
Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives.
A series of substituted chalcone oxides (1,3-diphenyl-2-oxiranyl propanones) and structural analogs was synthesized to… 
1992
1992
Influence of modulators of epoxide metabolism on the cytotoxicity of trans-anethole in freshly isolated rat hepatocytes.
The effect of modulating epoxide metabolism by inhibiting microsomal and cytosolic epoxide hydrolases and depleting glutathione… 
1986
1986
Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice.
An affinity purification procedure was developed for the cytosolic epoxide hydrolase based upon the selective binding of the… 
Highly Cited
1982
Highly Cited
1982
Chalcone oxides--potent selective inhibitors of cytosolic epoxide hydrolase.
The systematic screening of over 150 compounds for inhibitory activity on mammalian cytosolic epoxide hydrolase led to… 
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