ceramide metabolic process
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Major depression is a highly prevalent severe mood disorder that is treated with antidepressants. The molecular targets of… Expand The recent implementation of genomic and lipidomic approaches has produced a large body of evidence implicating the sphingolipid… Expand Sphingolipids are important components of eukaryotic cells, many of which function as bioactive signaling molecules. Of these… Expand Sphingolipids, which include ceramides and sphingosine, are essential structural components of cell membranes that also have… Expand Recent studies by our group and others have disclosed the presence of ceramides in mitochondria, and the activities of ceramide… Expand Ceramide, generated by the action of acid sphingomyelinase (ASM), has emerged as a biochemical mediator of stimuli as diverse as… Expand Recent years have witnessed significant advances in the understanding of the role of ceramide in apoptosis. This review… Expand The stratum corneum of the skin of patients with atopic dermatitis is highly susceptible to colonization by various bacteria… Expand Inherent or acquired drug resistance, which frequently characterizes cancer cells, is caused by multiple mechanisms, including… Expand BACKGROUND
We previously reported that N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide) treatment caused large increases of… Expand