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ceramidase activity

Known as: N-acylsphingosine amidohydrolase activity, acylsphingosine deacylase activity 
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. [EC:3.5.1.23]
National Institutes of Health

Papers overview

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2017
2017
Adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and lipid metabolism by mediating, at least… Expand
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Highly Cited
2015
Highly Cited
2015
Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. We have developed transgenic… Expand
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Highly Cited
2011
Highly Cited
2011
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell… Expand
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2010
2010
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell… Expand
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Highly Cited
2004
Highly Cited
2004
Advanced glycation end-products (AGE) are generated by chronic hyperglycaemia and may cause diabetic microvascular complications… Expand
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Highly Cited
2002
Highly Cited
2002
We examined the biological effects of the ceramide analogues (1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol (D-e-MAPP) and (1R,2R… Expand
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2001
2001
Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of… Expand
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2001
2001
A neutral ceramidase activity stimulated by bile salt was previously identified in the intestinal content. Recently, bile salt… Expand
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1999
1999
Acid ceramidase (N-acylsphingosine amidohydrolase) is the lysosomal enzyme required to hydrolyze the N-acyl linkage between the… Expand
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1994
1994
Ceramide is ubiquitously present in plasma membranes and plays a pivotal role in metabolism of sphingolipids. In addition… Expand
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