ceramidase activity

Known as: N-acylsphingosine amidohydrolase activity, acylsphingosine deacylase activity 
Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. [EC:3.5.1.23]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2018
0246819712018

Papers overview

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Highly Cited
2011
Highly Cited
2011
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases inflammation and promotes cell… (More)
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2004
2004
Human alveolar macrophages are unique in that they have an extended life span in contrast to precursor monocytes. In evaluating… (More)
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2004
2004
Advanced glycation end-products (AGE) are generated by chronic hyperglycaemia and may cause diabetic microvascular complications… (More)
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2003
2003
An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide… (More)
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2002
2002
We examined the biological effects of the ceramide analogues (1S,2R)-2-N-myristoylamino-1-phenyl-1-propanol (D-e-MAPP) and (1R,2R… (More)
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Highly Cited
2000
Highly Cited
2000
Ceramide is not only a core intermediate of sphingolipids but also an important modulator of many cellular events including… (More)
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1996
1996
In this study, we have examined the cellular and biochemical activities of the ceramide analog (1S,2R)-D-erythro-2-(N… (More)
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1995
1995
Sphingosine is a product of sphingolipid metabolism that has been linked to a protein kinase C-independent mitogenic response. In… (More)
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1994
1994
Ceramide is ubiquitously present in plasma membranes and plays a pivotal role in metabolism of sphingolipids. In addition… (More)
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1994
1994
To elucidate the mechanisms that are involved in the decrease of ceramide levels in atopic dry skin and in aged skin, we examined… (More)
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