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centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

centrosome cycle

Narrower (1)

mitotic centrosome separation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Mechanisms of centrosome separation and bipolar spindle assembly.
Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based… Expand
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Highly Cited
2010
Highly Cited
2010
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction
During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and… Expand
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Highly Cited
2008
Highly Cited
2008
A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila
Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a… Expand
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Highly Cited
2008
Highly Cited
2008
beta-Catenin is a Nek2 substrate involved in centrosome separation.
beta-Catenin plays important roles in cell adhesion and gene transcription, and has been shown recently to be essential for the… Expand
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Highly Cited
2007
Highly Cited
2007
Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression
Activation of cyclin B1–cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key… Expand
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Highly Cited
2004
Highly Cited
2004
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
Entry into mitosis occurs after activation of Cdk1, resulting in chromosome condensation in the nucleus and centrosome separation… Expand
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Highly Cited
2004
Highly Cited
2004
Myosin II-Dependent Cortical Movement Is Required for Centrosome Separation and Positioning during Mitotic Spindle Assembly
The role of myosin II in mitosis is generally thought to be restricted to cytokinesis. We present surprising new evidence that… Expand
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Highly Cited
2002
Highly Cited
2002
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
Centrosome duplication and separation are linked inextricably to certain cell cycle events, in particular activation of cyclin… Expand
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Highly Cited
1999
Highly Cited
1999
Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo
We have investigated the role of cytoplasmic dynein in microtubule organizing center (MTOC) positioning using RNA-mediated… Expand
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Highly Cited
1995
Highly Cited
1995
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
We show that female sterile mutations of aurora (aur) are allelic to mutations in the lethal complementation group ck10. This… Expand
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