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centrosome separation

The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

centrosome cycle

Narrower (1)

mitotic centrosome separation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction
During interphase, centrosomes are held together by a proteinaceous linker that connects the proximal ends of the mother and… 
Highly Cited
2009
Highly Cited
2009
Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
Highly Cited
2008
Highly Cited
2008
A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila
Centrosomes comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Here, we have performed a… 
Highly Cited
2008
Highly Cited
2008
beta-Catenin is a Nek2 substrate involved in centrosome separation.
beta-Catenin plays important roles in cell adhesion and gene transcription, and has been shown recently to be essential for the… 
Highly Cited
2008
Highly Cited
2008
Dynein, Lis1 and CLIP‐170 counteract Eg5‐dependent centrosome separation during bipolar spindle assembly
Bipolar spindle assembly critically depends on the microtubule plus‐end‐directed motor Eg5 that binds antiparallel microtubules… 
Highly Cited
2007
Highly Cited
2007
Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression
Activation of cyclin B1–cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key… 
Highly Cited
2004
Highly Cited
2004
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
Entry into mitosis occurs after activation of Cdk1, resulting in chromosome condensation in the nucleus and centrosome separation… 
Highly Cited
2002
Highly Cited
2002
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
Highly Cited
1999
Highly Cited
1999
Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo
We have investigated the role of cytoplasmic dynein in microtubule organizing center (MTOC) positioning using RNA-mediated… 
Highly Cited
1995
Highly Cited
1995
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
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