cathepsin K

Known as: Cathepsin K [Chemical/Ingredient], Cathepsin O, Cathepsin X 
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1971-2017
05010015019712017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Cathepsin K (CTSK) is secreted by osteoclasts to degrade collagen and other matrix proteins during bone resorption. Global… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Cathepsin K, a cysteine protease expressed in osteoclasts, degrades type 1 collagen. Odanacatib selectively and reversibly… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
BACKGROUND Cathepsin K (CatK), a potent elastinolytic and collagenolytic cysteine protease, likely participates in the evolution… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Human macrophages mediate the dissolution of elastic lamina by mobilizing tissue-destructive cysteine proteinases. While… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Cathepsin K is a cysteine protease expressed predominantly in osteoclasts. Activated cathepsin K cleaves key bone matrix proteins… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Cathepsin K (EC 3.4.22.38) is a recently described enzyme that has been shown to cleave type I collagen in its triple helix. The… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Pycnodysostosis, an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature, maps to… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes… (More)
  • figure 1
  • table I
  • table II
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Human cathepsin K is a recently identified protein with high primary sequence homology to members of the papain cysteine protease… (More)
Is this relevant?