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catalpol

 
National Institutes of Health

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Iridoid Glucosides

Papers overview

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Review
2019
Review
2019
Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related neurodegenerative disorders, affecting… Expand
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2016
2016
Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed
BackgroundDiabetes, associated with hyperlipidemia and oxidative stress, would lead to an increased production of reactive oxygen… Expand
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2015
2015
Catalpol ameliorates high-fat diet-induced insulin resistance and adipose tissue inflammation by suppressing the JNK and NF-κB pathways.
Catalpol, a bioactive component from the root of Rehmannia glutinosa, has been shown to possess hypoglycemic effects in type 2… Expand
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2013
2013
Catalpol improves cholinergic function and reduces inflammatory cytokines in the senescent mice induced by D-galactose.
The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh rehmannia roots, on the cholinergic system… Expand
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Highly Cited
2011
Highly Cited
2011
Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats.
Catalpol is one of the active principles from roots of Rehmannia glutinosa Steud (Scrophulariaceae) that is widely used to treat… Expand
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Highly Cited
2010
Highly Cited
2010
Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax.
Catalpol, an iridoid glucoside found in the root of Rehmannia glutinosa Libosch, has been demonstrated to reduce apoptosis in… Expand
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2010
2010
Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats
Diabetes mellitus can cause dysfunction of the central nervous system called "diabetic encephalopathy." Although insulin and… Expand
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Highly Cited
2009
Highly Cited
2009
Catalpol protects primary cultured cortical neurons induced by Aβ1–42 through a mitochondrial-dependent caspase pathway
It has been reported that catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa, protected cells from… Expand
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Highly Cited
2007
Highly Cited
2007
Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by d-galactose
The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh Rehmannia roots, on the senescent mice… Expand
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Highly Cited
2006
Highly Cited
2006
Catalpol protects dopaminergic neurons from LPS-induced neurotoxicity in mesencephalic neuron-glia cultures.
Inflammation plays an important role in the pathogenesis of Parkinson's disease (PD). Microglia, the resident immune cells in the… Expand
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