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caspase-9

Known as: ICE-LAP6 Protein, CASP9 Protein, MCH6 
A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Disruption of Akt and Erk-mediated signal transduction significantly contributes in the pathogenesis of various neurodegenerative… Expand
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Highly Cited
2000
Highly Cited
2000
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… Expand
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand
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Review
1999
Review
1999
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… Expand
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… Expand
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Highly Cited
1999
Highly Cited
1999
Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt… Expand
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Highly Cited
1998
Highly Cited
1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… Expand
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Highly Cited
1998
Highly Cited
1998
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… Expand
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Highly Cited
1998
Highly Cited
1998
Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… Expand
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Highly Cited
1997
Highly Cited
1997
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… Expand
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