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Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… Expand Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… Expand Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… Expand Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase… Expand Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… Expand Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… Expand Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… Expand We report here the purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase… Expand We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… Expand