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caspase-9

Known as: ICE-LAP6 Protein, CASP9 Protein, MCH6 
A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by… Expand
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
  • Toshiyuki Nakagawa, Hong Zhu, +4 authors Junying Yuan
  • Nature
  • 2000
  • Corpus ID: 205065930
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand
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Highly Cited
2000
Highly Cited
2000
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… Expand
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… Expand
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Review
1999
Review
1999
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… Expand
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Review
1999
Review
1999
Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase… Expand
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Highly Cited
1998
Highly Cited
1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… Expand
Highly Cited
1998
Highly Cited
1998
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… Expand
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Highly Cited
1998
Highly Cited
1998
Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… Expand
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Highly Cited
1998
Highly Cited
1998
We report here the purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase… Expand
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Highly Cited
1997
Highly Cited
1997
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… Expand
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