caspase-9

Known as: ICE-LAP6 Protein, CASP9 Protein, MCH6 
A long pro-domain caspase that contains a CASPASE RECRUITMENT DOMAIN in its pro-domain region. Caspase 9 is activated during cell stress by… (More)

Topic mentions per year

Topic mentions per year

1996-2018
020040060019962018

Papers overview

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Highly Cited
2002
Highly Cited
2002
Activation of caspase-12 from procaspase-12 is specifically induced by insult to the endoplasmic reticulum (ER) (Nakagawa, T… (More)
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Highly Cited
2001
Highly Cited
2001
X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as… (More)
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Highly Cited
2000
Highly Cited
2000
We report here the identification of a novel protein, Smac, which promotes caspase activation in the cytochrome c/Apaf-1/caspase… (More)
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… (More)
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… (More)
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Highly Cited
1999
Highly Cited
1999
We report here the reconstitution of the de novo procaspase-9 activation pathway using highly purified cytochrome c, recombinant… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a… (More)
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Highly Cited
1998
Highly Cited
1998
Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… (More)
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