caspase-8

Known as: CASP8 Protein, FADD-homologous ICE/CED3-Like Protease, CAP4 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and… (More)

Topic mentions per year

Topic mentions per year

1987-2018
020040019872018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Apoptosis and necroptosis are complementary pathways controlled by common signalling adaptors, kinases and proteases; among these… (More)
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Highly Cited
2008
Highly Cited
2008
The inflammatory response of mammalian cells to TNF-alpha can be switched to apoptosis either by cotreatment with a protein… (More)
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Highly Cited
2004
Highly Cited
2004
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially… (More)
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… (More)
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Highly Cited
2000
Highly Cited
2000
Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase… (More)
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Highly Cited
1998
Highly Cited
1998
We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in… (More)
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Highly Cited
1998
Highly Cited
1998
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the… (More)
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Highly Cited
1998
Highly Cited
1998
Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse… (More)
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Highly Cited
1998
Highly Cited
1998
The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs in a hierarchical manner; the death domain… (More)
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Highly Cited
1997
Highly Cited
1997
Induction of apoptosis by the cell surface receptor CD95 (APO-1/Fas) has been shown to involve activation of a family of cysteine… (More)
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