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caspase-8

Known as: CASP8 Protein, FADD-homologous ICE/CED3-Like Protease, CAP4 
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Inflammasomes are multiprotein innate immune complexes that regulate caspase-dependent inflammation and cell death. Pattern… Expand
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Highly Cited
2011
Highly Cited
2011
Apoptosis and necroptosis are complementary pathways controlled by common signalling adaptors, kinases and proteases; among these… Expand
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Highly Cited
2008
Highly Cited
2008
The inflammatory response of mammalian cells to TNF-alpha can be switched to apoptosis either by cotreatment with a protein… Expand
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Highly Cited
2004
Highly Cited
2004
Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially… Expand
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Highly Cited
2000
Highly Cited
2000
Apoptosis, or cellular suicide, is important for normal development and tissue homeostasis, but too much or too little apoptosis… Expand
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Highly Cited
2000
Highly Cited
2000
Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase… Expand
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Highly Cited
1998
Highly Cited
1998
We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in… Expand
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Highly Cited
1998
Highly Cited
1998
Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse… Expand
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Highly Cited
1998
Highly Cited
1998
Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) potentially initiates apoptosis and activates the… Expand
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Review
1997
Review
1997
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… Expand
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