caspase-6 activity

OBSOLETE (was not defined before being made obsolete). [GOC:mah]
National Institutes of Health

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caspase activity
caspase-6

Papers overview

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2015
2015
Sox11 Reduces Caspase-6 Cleavage and Activity
The apoptotic cascade is an orchestrated event, whose final stages are mediated by effector caspases. Regulatory binding proteins… (More)
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2012
2012
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
Huntington's disease (HD) is caused by a mutation in the huntingtin (htt) gene encoding an expansion of glutamine repeats at the… (More)
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2012
2012
A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C
Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease… (More)
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2011
2011
A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture
Aberrant activation of caspase-6 has recently emerged as a major contributor to the pathogeneses of neurodegenerative disorders… (More)
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Highly Cited
2010
Highly Cited
2010
Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway.
Surfactin has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms… (More)
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2009
2009
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell… (More)
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Highly Cited
2008
Highly Cited
2008
Targets of caspase-6 activity in human neurons and Alzheimer disease.
Caspase-6 activation occurs early in Alzheimer disease and sometimes precedes the clinical manifestation of the disease in aged… (More)
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Highly Cited
2002
Highly Cited
2002
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain
Caspase activation resulting from cytochrome c release from the mitochondria is an essential component of the mechanism of… (More)
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2001
2001
Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts. p38 MAPK is related in hypoxia-induced apoptosis.
The aim of this study is to elucidate the possible mechanism of apoptosis in response to hypoxia in MC3T3E1 osteoblasts. MC3T3E1… (More)
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Highly Cited
1999
Highly Cited
1999
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
Neuronal cell death, neurofibrillary tangles, and amyloid beta peptide (Abeta) deposition depict Alzheimer's disease (AD… (More)
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