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cariporide

 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsGuanidinesSulfones
Cariporide Mesylate

Narrower (2)

HOE 642HOE 694

Papers overview

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Highly Cited
2016
Highly Cited
2016
Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits
Aims/hypothesisEmpagliflozin (EMPA), an inhibitor of the renal sodium–glucose cotransporter (SGLT) 2, reduces the risk of… Expand
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Highly Cited
2015
Highly Cited
2015
New insights into the roles of CHOP-induced apoptosis in ER stress.
Yiming Li1, Yunshan Guo2, Juan Tang2*, Jianli Jiang2*, and Zhinan Chen2* Company Nine, Brigade of Undergraduates, The Fourth… Expand
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Review
2013
Review
2013
Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer…
In recent years an increasing number of publications have emphasized the growing importance of hydrogen ion dynamics in modern… Expand
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Highly Cited
2008
Highly Cited
2008
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study.
BACKGROUND The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen exchanger isoform-1 (NHE-1… Expand
Review
2005
Review
2005
The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention.
The Na(+)/H(+) exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher eukaryotes this integral membrane… Expand
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Highly Cited
2003
Highly Cited
2003
Cariporide (HOE642), a Selective Na+-H+ Exchange Inhibitor, Inhibits the Mitochondrial Death Pathway
Background—The Na+-H+ exchanger figures prominently in cardiac ischemia-reperfusion injury. Several experimental and clinical… Expand
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Highly Cited
2003
Highly Cited
2003
Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions.
The mechanism by which inhibition of Na+/H+ exchanger (NHE) reduces cell death in ischemic-reperfused myocardium remains… Expand
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Highly Cited
2000
Highly Cited
2000
Inhibition of the Sodium-Hydrogen Exchanger With Cariporide to Prevent Myocardial Infarction in High-Risk Ischemic Situations: Main Results of the GUARDIAN Trial
Background—The transmembrane sodium/hydrogen exchanger maintains myocardial cell pH integrity during myocardial ischemia but… Expand
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Highly Cited
2000
Highly Cited
2000
Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA.
BACKGROUND Activation of Na(+)/H(+) exchange in myocardial ischemia and/or reperfusion leads to calcium overload and myocardial… Expand
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Highly Cited
1999
Highly Cited
1999
Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective.
In myocardial ischemia, rapid inactivation of Na(+)-K(+)-ATPase and continuing influx of sodium induce Na(+)-overload which is… Expand
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