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cariporide

 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Anti-Arrhythmia AgentsGuanidinesSulfones
Cariporide Mesylate

Narrower (2)

HOE 642HOE 694

Papers overview

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Highly Cited
2016
Highly Cited
2016
Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits
Aims/hypothesisEmpagliflozin (EMPA), an inhibitor of the renal sodium–glucose cotransporter (SGLT) 2, reduces the risk of… Expand
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Review
2013
Review
2013
Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer…
In recent years an increasing number of publications have emphasized the growing importance of hydrogen ion dynamics in modern… Expand
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Highly Cited
2011
Highly Cited
2011
Negative tracheal pressure during obstructive respiratory events promotes atrial fibrillation by vagal activation.
BACKGROUND Obstructive sleep apnea (OSA) causes negative tracheal pressure (NTP) and is associated with atrial fibrillation (AF… Expand
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Highly Cited
2008
Highly Cited
2008
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study.
BACKGROUND The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen exchanger isoform-1 (NHE-1… Expand
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Highly Cited
2003
Highly Cited
2003
Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions.
The mechanism by which inhibition of Na+/H+ exchanger (NHE) reduces cell death in ischemic-reperfused myocardium remains… Expand
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Highly Cited
2003
Highly Cited
2003
Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway.
BACKGROUND The Na+-H+ exchanger figures prominently in cardiac ischemia-reperfusion injury. Several experimental and clinical… Expand
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2001
2001
Attenuation of compensatory right ventricular hypertrophy and heart failure following monocrotaline-induced pulmonary vascular injury by the Na+-H+ exchange inhibitor cariporide.
Pulmonary hypertension results in compensatory right ventricular (RV) hypertrophy. We studied the role of the Na+-H+ exchange… Expand
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Highly Cited
2000
Highly Cited
2000
Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against…
BACKGROUND The transmembrane sodium/hydrogen exchanger maintains myocardial cell pH integrity during myocardial ischemia but… Expand
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Highly Cited
2000
Highly Cited
2000
Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA.
BACKGROUND Activation of Na(+)/H(+) exchange in myocardial ischemia and/or reperfusion leads to calcium overload and myocardial… Expand
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Highly Cited
1999
Highly Cited
1999
Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective.
In myocardial ischemia, rapid inactivation of Na(+)-K(+)-ATPase and continuing influx of sodium induce Na(+)-overload which is… Expand
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