cargo loading into vesicle
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Extracellular vesicles are a heterogeneous group of membrane-limited vesicles loaded with various proteins, lipids, and nucleic… Expand Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a… Expand Autophagy delivers cytosolic components to lysosomes for their degradation. The delivery of autophagic cargo to late endosomes… Expand Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are… Expand Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to… Expand Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved… Expand Selective incorporation of cargo proteins into the forming vesicle is an important aspect of protein targeting via vesicular… Expand We have characterized the mechanisms of cargo selection into ER-derived vesicles by the COPII subunit Sec24p. We identified a… Expand Clathrin-mediated endocytosis involves cargo selection and membrane budding into vesicles with the aid of a protein coat… Expand The proper functioning of eukaryotic organelles is largely dependent on the specific packaging of cargo proteins within transient… Expand