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carboxytolbutamide

Known as: 1-butyl-3-(4-carboxyphenyl)sulfonylurea, 4-(((butylamino)carbonyl)amino)sulfonylbenzoic acid, tolbutamide carboxylic acid 
 
National Institutes of Health

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Broader (1)

Tolbutamide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.
A liquid chromatography/mass spectrometry method, for rapid determination of five cytochrome P450 (CYP) probe drugs and their… Expand
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Highly Cited
2003
Highly Cited
2003
Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.
AIM Our goal was to investigate whether artemisinin autoinduction is caused by an increase in cytochrome P450 (CYP) 2B6 or CYP2C9… Expand
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2003
2003
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans.
The metabolic activity of CYP2C9 in 16 subjects expressing four different genotypes (CYP2C9*1/*1, *1/*2, *1/*3, and *2/*2) was… Expand
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2002
2002
Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.
OBJECTIVES Multiple single-nucleotide polymorphisms in the gene encoding cytochrome P450 (CYP) 2C9 have been identified, but the… Expand
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1990
1990
Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.
The present study has validated kinetically a convenient method to measure tolbutamide hydroxylation capacity in human beings by… Expand
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1988
1988
Characterization of the sulfonylurea receptor on beta cell membranes.
Specific, high affinity sulfonylurea receptors were characterized on membranes of an insulin-secreting hamster beta cell line… Expand
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1986
1986
Inhibition of tolbutamide elimination by cimetidine but not ranitidine.
This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine… Expand
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1981
1981
High-performance liquid chromatographic assay of tolbutamide and carboxytolbutamide in human plasma.
A high-performance liquid chromatographic method was developed for the simultaneous measurement of tolbutamide and its major… Expand
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1962
1962
Influence of the absorption rate of tolbutamide on the rate of decline of blood sugar levels in normal humans.
The absorption of tolbutamide and several of its salts was studied by means of carboxytolbutamide excretion rate measurements… Expand
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1961
1961
Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration.
The excretion kinetics of carboxytolbutamide after the oral ingestion of sodium tolbutamide of tolbutamide or tolbutamide free… Expand
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