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carboxytolbutamide

Known as: 1-butyl-3-(4-carboxyphenyl)sulfonylurea, 4-(((butylamino)carbonyl)amino)sulfonylbenzoic acid, tolbutamide carboxylic acid 
 
National Institutes of Health

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Broader (1)

Tolbutamide
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies.
A liquid chromatography/mass spectrometry method, for rapid determination of five cytochrome P450 (CYP) probe drugs and their… Expand
Highly Cited
2003
Highly Cited
2003
Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9
Our goal was to investigate whether artemisinin autoinduction is caused by an increase in cytochrome P450 (CYP) 2B6 or CYP2C9… Expand
Highly Cited
2002
Highly Cited
2002
Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C9*1 heterozygotes
Multiple single‐nucleotide polymorphisms in the gene encoding cytochrome P450 (CYP) 2C9 have been identified, but the functional… Expand
Highly Cited
2001
Highly Cited
2001
Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide
Our objective was to examine the interaction between fluvoxamine and tolbutamide to confirm that fluvoxamine inhibits CYP2C9. 
Highly Cited
1996
Highly Cited
1996
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
Publisher Summary This chapter describes an established high-performance liquid chromatographic (HPLC) assay for the measurement… Expand
Highly Cited
1990
Highly Cited
1990
Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers
The present study has validated kinetically a convenient method to measure tolbutamide hydroxylation capacity in human beings by… Expand
Highly Cited
1988
Highly Cited
1988
Characterization of the sulfonylurea receptor on beta cell membranes.
Specific, high affinity sulfonylurea receptors were characterized on membranes of an insulin-secreting hamster beta cell line… Expand
1986
1986
Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine
This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine… Expand
1981
1981
High-performance liquid chromatographic assay of tolbutamide and carboxytolbutamide in human plasma.
A high-performance liquid chromatographic method was developed for the simultaneous measurement of tolbutamide and its major… Expand
1961
1961
Kinetics of carboxytolbutamide excretion following tolbutamide and carboxytolbutamide administration.
The excretion kinetics of carboxytolbutamide after the oral ingestion of sodium tolbutamide of tolbutamide or tolbutamide free… Expand
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