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carbapenem biosynthetic process

Known as: carbapenem biosynthesis, carbapenem anabolism, carbapenem synthesis 
The chemical reactions and pathways resulting in the formation of carbapenem. [GOC:TermGenie, GOC:yaf, PMID:9402024, UniPathway:UPA00182]
National Institutes of Health

Papers overview

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2014
2014
Useful population biocatalysts in carbapenem synthesis
The present disclosure provides a useful artificial pNB esterase polypeptide to the synthesis of carbapenem antibiotics imipenem… 
2014
2014
Engineered biocatalysts useful for carbapenem synthesis
The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic… 
Highly Cited
2005
Highly Cited
2005
The enzymology of clavam and carbapenem biosynthesis.
The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including beta-amino acid and… 
2005
2005
Structural and Mechanistic Studies on Carboxymethylproline Synthase (CarB), a Unique Member of the Crotonase Superfamily Catalyzing the First Step in Carbapenem Biosynthesis*
The first step in the biosynthesis of the medicinally important carbapenem family of β-lactam antibiotics is catalyzed by… 
2004
2004
Crystal of carbapenem synthesis intermediates
2003
2003
Synthesis of (3S,5R)-carbapenam-3-carboxylic acid and its role in carbapenem biosynthesis and the stereoinversion problem.
(5R)-Carbapenem-3-carboxylic acid is the simplest structurally among the naturally occurring carbapenem beta-lactam antibiotics… 
2002
2002
Improved process for carbapenem synthesis
The present invention relates to a salt thereof that is acceptable as synthesis method, a compound or pharmaceutical of formula… 
2000
2000
Site-directed mutagenesis and biochemical analysis of the endogenous ligands in the ferrous active site of clavaminate synthase. The His-3 variant of the 2-His-1-carboxylate model.
The facial 2-His-1-carboxylate (Asp/Glu) motif has emerged as the structural paradigm for metal binding in the alpha… 
1996
1996
Analysis of bacterial carbapenem antibiotic production genes reveals a novel beta-lactam biosynthesis pathway.
Carbapenems are beta-lactam antibiotics which have an increasing utility in chemotherapy, particularly for nosocomial, multidrug… 
1985
1985
Studies on the biosynthesis of carbapenem antibiotics. IV. Beta-alanine in the C-3 pantetheinyl side chain of the OA-6129 group of carbapenems.
Radioactive beta-alanine was specifically incorporated into the beta-alanine moiety of the C-3 pantetheinyl side chain of the OA… 
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