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Tacrolimus exerts its immunosuppressive effect through inhibition of the intracellular enzyme calcineurin phosphatase… Expand BACKGROUND
Regardless of the extensive worldwide use of calcineurin inhibitors, little is known about the behavior of calcineurin… Expand Cyclosporine A (CsA) is metabolized into a vast spectrum of metabolites. The potential immunosuppressive action of CsA's… Expand The pharmacodynamic (PD) action of tacrolimus (FK) within the T-cell is inhibition of calcineurin phosphatase (CaN… Expand Cyclosporin and tacrolimus remain the cornerstone immunosuppressive drugs in organ transplantation. Dosing and monitoring these… Expand Calcineurin phosphatase (CaN) activity has been the focus of several recent studies on renal transplant patients as the… Expand BACKGROUND
The calcineurin inhibitors cyclosporine and tacrolimus are used as primary immunosuppressive drugs in transplant… Expand Prolactin (PRL) is produced in human thymocytes, T-cells and endometrium. In these extrapituitary tissues, PRL gene transcription… Expand Recent reports have shown that cyclosporine (CsA)-treated patients have abundant calcineurin phosphatase (CN) activity in vivo… Expand Despite increasing information about the mechanism of action of cyclosporine A (CsA), little is known about the way lymphocytes… Expand