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cGMP Phosphodiesterase Inhibitor

Any substance that inhibits cGMP phosphodiesterase, an enzyme that breaks the phosphodiester bond in cGMP. Inhibition of cGMP phosphodiesterase can… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn… Expand
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Highly Cited
2005
Highly Cited
2005
Vasopressin-stimulated insertion of the aquaporin 2 (AQP2) water channel into the plasma membrane of kidney collecting duct… Expand
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Highly Cited
2003
Highly Cited
2003
The small G protein RhoA is a convergence point for multiple signals that regulate smooth muscle cell functions. NO plays a major… Expand
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Highly Cited
2000
Highly Cited
2000
Store-operated Ca2+ entry in vascular endothelial cells not only serves to refill the intracellular Ca2+ stores, but also acts to… Expand
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1998
1998
PURPOSE The primary mechanism for relaxation of corpus cavernosum smooth muscle (CCSM) and penile erection depends upon nitric… Expand
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Highly Cited
1998
Highly Cited
1998
Nitric oxide activates guanylate cyclase to form cGMP, comprising a signalling system that is believed to be a distinct mechanism… Expand
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To investigate further the mechanisms of action of sildenafil, a highly selective and potent inhibitor of type 5 cGMP… Expand
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Highly Cited
1995
Highly Cited
1995
Endogenous nitric oxide (NO) modulates fetal pulmonary vascular tone by stimulating guanosine 3',5'-cyclic monophosphate (cGMP… Expand
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Highly Cited
1995
Highly Cited
1995
We investigated the effect of zaprinast (M&B 22948), a specific cGMP phosphodiesterase inhibitor, on pulmonary arteries isolated… Expand
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1993
1993
To investigate the hypothesis that pulmonary vascular tone and endothelium-dependent pulmonary vasodilation are mediated by… Expand
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