cGMP Phosphodiesterase Inhibitor

Any substance that inhibits cGMP phosphodiesterase, an enzyme that breaks the phosphodiester bond in cGMP. Inhibition of cGMP phosphodiesterase can… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2013
012319882013

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2005
2005
BACKGROUND Chronic renal disease is associated with oxidative stress and reduced nitric oxide availability which, in turn… (More)
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2003
2003
In this study, we evaluated the effects of oral administration of DA-8159, a selective phosphodiesterase-5 inhibitor, on the… (More)
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Highly Cited
2003
Highly Cited
2003
The small G protein RhoA is a convergence point for multiple signals that regulate smooth muscle cell functions. NO plays a major… (More)
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1999
1999
Introduction: Congenital diaphragmatic hernia (CDH) remains a frustating cause of respiratory failure associated with persistent… (More)
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1998
1998
PURPOSE The primary mechanism for relaxation of corpus cavernosum smooth muscle (CCSM) and penile erection depends upon nitric… (More)
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1998
1998
Nitric oxide activates guanylate cyclase to form cGMP, comprising a signalling system that is believed to be a distinct mechanism… (More)
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1997
1997
OBJECTIVE To investigate further the mechanisms of action of sildenafil, a highly selective and potent inhibitor of type 5 cGMP… (More)
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1995
1995
We investigated the effect of zaprinast (M&B 22948), a specific cGMP phosphodiesterase inhibitor, on pulmonary arteries isolated… (More)
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1995
1995
Endogenous nitric oxide (NO) modulates fetal pulmonary vascular tone by stimulating guanosine 3',5'-cyclic monophosphate (cGMP… (More)
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1993
1993
To investigate the hypothesis that pulmonary vascular tone and endothelium-dependent pulmonary vasodilation are mediated by… (More)
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