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The antiepidermal growth factor receptor monoclonal antibody cetuximab has improved survival in patients with metastatic… Expand BACKGROUND
This study was designed to determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of brivanib in… Expand Tumor angiogenesis is a complex and tightly regulated network mediated by various proangiogenic factors. The fibroblast growth… Expand PURPOSE
Tamoxifen, a selective oestrogen receptor modulator (SERM), and brivanib alaninate, a vascular endothelial growth factor… Expand Fibroblast growth factor receptor-1 (FGFR-1) is amplified in 10% of human breast cancers. The goal of this study was to test the… Expand PurposeBrivanib alaninate is a prodrug of brivanib (BMS-540215), a potent oral VEGFR-2 inhibitor and is currently in development… Expand Purpose: Hepatocellular carcinoma (HCC) is the fifth most common primary neoplasm; surgery is the only curative option but 5-year… Expand A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to… Expand Two N-acyl amino acid surfactants, sodium N-(11-acrylamidoundecanoyl)-glycinate (SAUG) and L-alaninate (SAUA), were synthesized… Expand A cyclodextrin‐modified micellar electrokinetic chromatography (CD‐MEKC) method was applied to the enantioseparation of three… Expand