bone metastases

Known as: Secondary malignant neoplasm of bone and bone marrow, metastatic bone tumor, Metastatic Cancer to the Bone 
The spread of a malignant neoplasm from a primary site to the skeletal system. The majority of metastatic neoplasms to the bone are carcinomas.

Topic mentions per year

Topic mentions per year

1939-2018
0500100019392017

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Bone metastases are a major burden in men with advanced prostate cancer. We compared denosumab, a human monoclonal… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may promote the… (More)
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Highly Cited
2011
Highly Cited
2011
HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE This randomized study compared denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor… (More)
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Highly Cited
2008
Highly Cited
2008
A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To investigate the efficacy and safety of zoledronic acid for the treatment of bone metastases from breast cancer… (More)
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Highly Cited
2003
Highly Cited
2003
We investigated the molecular basis for osteolytic bone metastasis by selecting human breast cancer cell line subpopulations with… (More)
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Highly Cited
2003
Highly Cited
2003
Osteoblastic bone metastases are common in prostate and breast cancer patients, but mechanisms by which tumor cells stimulate new… (More)
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Highly Cited
1999
Highly Cited
1999
Breast cancer frequently metastasizes to the skeleton, and the associated bone destruction is mediated by the osteoclast. Growth… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Bisphosphonates such as pamidronate disodium inhibit osteoclast-induced bone resorption associated with cancer that… (More)
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