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bizelesin

Known as: Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*)))-, benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*)), Benzo[1,2-b:4,3-b']dipyrrol-4-ol, 6, 6'-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))] 
A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of… Expand
National Institutes of Health

Papers overview

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2004
2004
Bizelesin (NSC-615291), a potent, bifunctional analog of the cyclopropylpyrroloindole antitumor antibiotics CC-1065 and… Expand
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2003
2003
BACKGROUND The aim of this study was to assess the feasibility of administering bizelesin, a cyclopropylpyrroloindole with… Expand
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2002
2002
PURPOSE To evaluate the toxicities, characterize the pharmacokinetics, and determine the maximum-tolerated dose of bizelesin… Expand
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Review
2001
Review
2001
DNA is a well characterized intracellular target but its large size and sequential nature make it an elusive target for selective… Expand
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1996
1996
Abstract Bizelesin is a potent synthetic derivative of the anticancer agent CC-1065 that preferentially alkylates and binds the… Expand
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1996
1996
Bizelesin (U-77779, NSC 615291), a synthetic analogue of the cytotoxic antibiotic CC-1065, is a bifunctional alkylating agent… Expand
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1995
1995
Bizelesin is a bifunctional covalent minor groove binding agent which forms adducts with 3'-adenines on opposite DNA strands. DNA… Expand
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1994
1994
In this study, we have mapped the intracellular alkylation sites of adozelesin and bizelesin, two potent analogs of CC-1065, in… Expand
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1993
1993
1H NMR analysis of the bizelesin adduct of d(CGTAATTACG)2 indicates that adenines six base pairs apart on opposite DNA strands… Expand
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1993
1993
Bizelesin, a cyclopropylpyrroloindole (CPI) antitumor agent, has been shown to alkylate and cross-link DNA within A/T-rich tracts… Expand
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