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bizelesin

Known as: Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*)))-, benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*)), Benzo[1,2-b:4,3-b']dipyrrol-4-ol, 6, 6'-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))] 
A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of… 
National Institutes of Health

Papers overview

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2004
2004
Bizelesin (NSC-615291), a potent, bifunctional analog of the cyclopropylpyrroloindole antitumor antibiotics CC-1065 and… 
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2003
2003
BACKGROUND The aim of this study was to assess the feasibility of administering bizelesin, a cyclopropylpyrroloindole with… 
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2002
2002
PURPOSE To evaluate the toxicities, characterize the pharmacokinetics, and determine the maximum-tolerated dose of bizelesin… 
Review
2001
Review
2001
DNA is a well characterized intracellular target but its large size and sequential nature make it an elusive target for selective… 
Review
1999
Review
1999
In this review, both cationic and neutral synthetic ligands that bind in the minor groove of DNA are discussed. Certain bis… 
1996
1996
Abstract Bizelesin is a potent synthetic derivative of the anticancer agent CC-1065 that preferentially alkylates and binds the… 
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1996
1996
Bizelesin (U-77779, NSC 615291), a synthetic analogue of the cytotoxic antibiotic CC-1065, is a bifunctional alkylating agent… 
1995
1995
The DNA cross-linker bizelesin has been previously shown to form interhelical interstrand cross-links with adenine residues six… 
1994
1994
In this study, we have mapped the intracellular alkylation sites of adozelesin and bizelesin, two potent analogs of CC-1065, in… 
1993
1993
1H NMR analysis of the bizelesin adduct of d(CGTAATTACG)2 indicates that adenines six base pairs apart on opposite DNA strands…