bimagrumab

A human monoclonal antibody directed against type II activin receptors (ActRII; ActR2), with potential muscle-sparing and anti-cachectic activities… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2018
024620142018

Papers overview

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2018
2018
AIM To test the hypothesis that an improving body composition in insulin-resistant individuals could enhance insulin sensitivity… (More)
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2018
2018
BACKGROUND Bimagrumab is a human monoclonal antibody inhibitor of activin type II receptors (ActRII), with anabolic action on… (More)
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2018
2018
PURPOSE Inhibitors of the ActRII signaling pathways represent promising therapeutics for the treatment of muscular diseases, but… (More)
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2017
2017
OBJECTIVES To assess the effects of bimagrumab on skeletal muscle mass and function in older adults with sarcopenia and mobility… (More)
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2017
2017
BACKGROUND Patients experiencing disuse atrophy report acute loss of skeletal muscle mass which subsequently leads to loss of… (More)
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2016
2016
Bimagrumab (BYM338) is a novel fully human monoclonal antibody that exerts strong promyogenic effects on skeletal muscle by… (More)
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2016
2016
RATIONALE A plethora of compounds potentially leading to drug candidates that affect skeletal muscle function and, more… (More)
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2014
2014
OBJECTIVE To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies… (More)
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Highly Cited
2014
Highly Cited
2014
The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in regulating skeletal muscle size… (More)
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Review
2014
Review
2014
Age-related loss of muscle mass and function, termed sarcopenia, is a catastrophic process, which impacts severely on quality of… (More)
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