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bicalutamide

Known as: (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-, 4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide 
A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the… 
National Institutes of Health

Related topics

Related topics

16 relations

Broader (5)

Androgen AntagonistsAnilidesAntineoplastic AgentsNitriles
Androgen Receptor Antagonists [MoA]Drug AllergyNCIt Antineoplastic Agent TerminologyPregnancy

Narrower (2)

CasodexICI-176334

Papers overview

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2013
2013
Bicalutamide-CYP 46 A 1 interactions 1 Binding of a Cyano-and Fluoro-Containing Drug Bicalutamide to Cytochrome P 450 46 A 1 : Unusual Features and Spectral Response *
  • 2013
  • Corpus ID: 343151
Background: Cytochrome P450 46A1 is important for normal brain function. Results: The X-ray structures of P450 46A1 were… 
2012
2012
Role of dutasteride in pre‐clinical ETS fusion‐positive prostate cancer models
Androgens play a crucial role in prostate cancer, hence the androgenic pathway has become an important target of therapeutic… 
2012
2012
Evaluation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy in antagonizes therapeutic
Purpose— To characterize the importance of cellular Fas-associated death domain (FADD)-like interleukin 1 β -converting enzyme… 
2011
2011
THE RELEVANCE OF CDx BRUSH BIOPSY IN DIAGNOSING EARLY ORAL CANCER IN DEVELOPING COUNTRIES
Squamous cell Carcinoma of oral mucosa is the most common type of cancer in males and third most common type in females in the… 
2010
2010
DISSOLUTION RATE ENHANCEMENT OF POORLY SOLUBLE BICALUTAMIDE USING β­ CYCLODEXTRIN INCLUSION COMPLEXATION
The purpose of this study was to improve the dissolution rate of poorly soluble bicalutamide drug with cyclodextrin complexation… 
2004
2004
Cdx 1 induced intestinal metaplasia in the transgenic mouse stomach : comparative study with Cdx 2 transgenic mice
Background and aims: Gastric intestinal metaplasia, which is mainly induced by Helicobacter pylori infection, is thought to be a… 
1999
1999
A low-cost multichannel Thomson scattering system for CDX-U
A multichannel Thomson scattering system has been developed for the CDX-U spherical torus. The system is designed for 10 eV 1018… 
1996
1996
Absence of hepatic enzyme induction in prostate cancer patients receiving `Casodex' (bicalutamide)
The potential for hepatic enzyme induction by bicalutamide (`Casodex‘) was assessed in an open study in prostate cancer patients… 
1983
1983
Epizootiological studies on R plasmid with carbadox resistance.
A total of 930 Escherichia coli strains, consisting of 307 strains isolated from cattle, 414 from swine, and 209 from chickens… 
1983
1983
The absorption of intramuscular chlordiazepoxide (Librium) in patients with severe alcoholic liver disease.
Intramuscular chlordiazepoxide (CDX) is commonly administered to alcoholic liver disease (ALD) patients requiring prompt…