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bicalutamide

Known as: (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-, 4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide 
A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
PURPOSE Enzalutamide, a potent oral androgen receptor inhibitor, improves survival in men with metastatic castration-resistant… Expand
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Highly Cited
2013
Highly Cited
2013
PURPOSE Patients with hormone receptor-negative breast cancer generally do not benefit from endocrine-targeted therapies. However… Expand
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Highly Cited
2011
Highly Cited
2011
Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify… Expand
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Highly Cited
2009
Highly Cited
2009
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive… Expand
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Highly Cited
2005
Highly Cited
2005
Carcinoma of the prostate is the most commonly diagnosed cancer in men. The current pharmacological treatment of choice for… Expand
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Highly Cited
2005
Highly Cited
2005
Androgen ablation therapies are effective in controlling prostate cancer. Although most cancers relapse and progress despite… Expand
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Highly Cited
2003
Highly Cited
2003
Most prostate cancers (PCs) become resistant to combined androgen blockade therapy with surgical or medical castration and… Expand
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Highly Cited
2002
Highly Cited
2002
Mouse Cdx and Hox genes presumably evolved from genes on a common ancestor cluster involved in anteroposterior patterning… Expand
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Highly Cited
2002
Highly Cited
2002
Initiation of Hox genes requires interactions between numerous factors and signaling pathways in order to establish their precise… Expand
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Highly Cited
1999
Highly Cited
1999
SummaryAdvanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to… Expand
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