bicalutamide

Known as: (+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide, Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-, 4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide 
A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the… (More)

Topic mentions per year

Topic mentions per year

1973-2017
05019732017

Papers overview

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Highly Cited
2014
Highly Cited
2014
Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor with early dissemination and dismal prognosis, accounts for 15… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Patients with hormone receptor-negative breast cancer generally do not benefit from endocrine-targeted therapies. However… (More)
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Highly Cited
2011
Highly Cited
2011
Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify… (More)
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Highly Cited
2009
Highly Cited
2009
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive… (More)
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Highly Cited
2005
Highly Cited
2005
Androgen ablation therapies are effective in controlling prostate cancer. Although most cancers relapse and progress despite… (More)
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Highly Cited
2003
Highly Cited
2003
Most prostate cancers (PCs) become resistant to combined androgen blockade therapy with surgical or medical castration and… (More)
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Highly Cited
2002
Highly Cited
2002
Prostate cancers (PCa) that relapse after androgen deprivation therapy invariably express high levels of androgen receptor (AR… (More)
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Highly Cited
2002
Highly Cited
2002
Initiation of Hox genes requires interactions between numerous factors and signaling pathways in order to establish their precise… (More)
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Highly Cited
1999
Highly Cited
1999
SummaryAdvanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to… (More)
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Highly Cited
1999
Highly Cited
1999
The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR… (More)
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