biapenem

Known as: (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)]-thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate, 3-((6,7-dihydro-5H-pyrazolo(1,2-a)(1,2,4)triazol-4-ium-6-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3,2,0)hept-2-ene-2-carboxylate, 5H-Pyrazolo(1,2-a)(1,2,4)triazol-4-ium, 6-((2-carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)thio)-6,7-dihydro-, hydroxide, inner salt, (4R-(4alpha,5beta,6beta(R*)))- 
A 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem… (More)
National Institutes of Health

Papers overview

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2013
2013
OBJECTIVES The proliferation of carbapenemases in Enterobacteriaceae demands new therapies, with current interest centred on… (More)
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2013
2013
Biapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine β-lactamases. Biapenem was tested… (More)
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2008
2008
BACKGROUND A pharmacokinetic-pharmacodynamic (PK-PD) target attainment analysis to build a dosing strategy for biapenem in adult… (More)
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2008
2008
Biapenem is a parenteral carbapenem antibiotic that exhibits wide-ranging antibacterial activity, remarkable chemical stability… (More)
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2005
2005
One strategy developed by bacteria to resist the action of beta-lactam antibiotics is the expression of metallo-beta-lactamases… (More)
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2005
2005
The alternative sigma factor, RpoS has been described as a central regulator of many stationary phase-inducible genes and a… (More)
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1998
1998
The pharmacokinetics and tolerability of a new parenteral carbapenem antibiotic, biapenem (L-627), were studied in healthy… (More)
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Highly Cited
1996
Highly Cited
1996
Consecutive klebsiellae were collected from ICU patients at 35 centres in Western and Southern Europe. Of 966 isolates obtained… (More)
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1995
1995
Biological activities of biapenem, imipenem, and meropenem were compared with respect to permeability into Gram-negative bacteria… (More)
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1993
1993
Biapenem is a new carbapenem antibiotic with high stability to human renal dehydropeptidase I. Its in vitro activity was compared… (More)
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