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biapenem

Known as: (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a] [1,2,4] triazolium-6-yl)]-thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate, 3-((6,7-dihydro-5H-pyrazolo(1,2-a)(1,2,4)triazol-4-ium-6-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3,2,0)hept-2-ene-2-carboxylate, 5H-Pyrazolo(1,2-a)(1,2,4)triazol-4-ium, 6-((2-carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)thio)-6,7-dihydro-, hydroxide, inner salt, (4R-(4alpha,5beta,6beta(R*)))- 
A 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
OBJECTIVES The proliferation of carbapenemases in Enterobacteriaceae demands new therapies, with current interest centred on… Expand
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2013
2013
ABSTRACT Biapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine β-lactamases. Biapenem… Expand
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Review
2009
Review
2009
Pseudomonas aeruginosa is an important cause of nosocomial pneumonia associated with a high morbidity and mortality rate. This… Expand
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Highly Cited
2005
Highly Cited
2005
One strategy developed by bacteria to resist the action of beta-lactam antibiotics is the expression of metallo-beta-lactamases… Expand
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Review
2000
Review
2000
During the last few decades, several carbapenems have been developed. The major characteristic of the newer drugs, such as MK-826… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT The in vitro and in vivo antibacterial activities of S-4661, a new 1β-methylcarbapenem, were compared with those of… Expand
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Highly Cited
1996
Highly Cited
1996
Consecutive klebsiellae were collected from ICU patients at 35 centres in Western and Southern Europe. Of 966 isolates obtained… Expand
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Highly Cited
1995
Highly Cited
1995
Biological activities of biapenem, imipenem, and meropenem were compared with respect to permeability into Gram-negative bacteria… Expand
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Highly Cited
1994
Highly Cited
1994
MICs of six extended-spectrum cephalosporins (cefotaxime, ceftriaxone, ceftazidime, FK 037, cefpirome, cefepime), three… Expand
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1993
1993
Susceptibilities of 539 Gram-positive and Gram-negative anaerobes were tested by agar dilution against 15 new and existing… Expand
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