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beta-carotene 15,15'-dioxygenase activity

Known as: carotene dioxygenase activity, beta-carotene 15,15'-monooxygenase activity, beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving) 
Catalysis of the reaction: beta-carotene + O(2) = 2 retinal. [EC:1.14.99.36, RHEA:10407]
National Institutes of Health

Papers overview

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2001
2001
beta-Carotene 15,15'-Dioxygenase activity in human tissues and cells: evidence of an iron dependency.
2000
2000
Beta-carotene 15,15'-dioxygenase activity in streptozotocin-induced diabetic rats.
We measured retinol levels and beta-carotene 15,15'-dioxygenase activity in rats with streptozotocin-induced diabetes mellitus to… 
2000
2000
Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids.
Beta-carotene-15,15'-dioxygenase is an enzyme responsible for providing vertebrates with vitamin A by catalyzing oxidative… 
Highly Cited
2000
Highly Cited
2000
Nutritional status affects intestinal carotene cleavage activity and carotene conversion to vitamin A in rats.
Validation of an in vivo method we developed recently and its application to assess the role of dietary factors in carotene… 
Highly Cited
1998
Highly Cited
1998
Characterization of beta-carotene 15,15'-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2.
The purpose of this study was to identify mammalian cell line(s) which possess intrinsic enzymatic activity of beta-carotene 15… 
Highly Cited
1998
Highly Cited
1998
beta-carotene 15,15'-dioxygenase activity and cellular retinol-binding protein type II level are enhanced by dietary unsaturated triacylglycerols in rat intestines.
The purpose of this study was to examine effects of dietary triacylglycerols on beta-carotene 15,15'-dioxygenase (EC 1.13.11.21… 
1996
1996
Assay of beta-carotene 15,15'-dioxygenase activity by reverse-phase high-pressure liquid chromatography.
beta-Carotene 15,15'-dioxygenase catalyzes the conversion of beta-carotene into two molecules of retinal. Although this enzyme… 
Highly Cited
1996
Highly Cited
1996
Rat intestinal beta-carotene dioxygenase activity is located primarily in the cytosol of mature jejunal enterocytes.
The purposes of this study were to determine the location of beta-carotene dioxygenase (EC 1.13.11.21) activity within the rat… 
Highly Cited
1994
Highly Cited
1994
β-Carotene-15,15′-dioxygenase (EC 1.13.11.21) isolation reaction mechanism and an improved assay procedure
βCarotene-15,15′-dioxygenase (EC 1.13.11.21; β-carotene dioxygenase) activity in extracts from guinea-pig intestinal mucosa was… 
Highly Cited
1986
Highly Cited
1986
Carotene dioxygenase (EC 1. 13. 11. 21) activity in rat intestine: effects of vitamin A deficiency and of pregnancy
1. Female weanling rats were fed on a purified diet containing either no vitamin A, apart from traces present in casein… 
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