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beta-adrenergic receptor kinase inhibitory peptide

Known as: betaARK1 inhibitor, betaARKct peptide, beta-adrenergic receptor kinase inhibitor 
 
National Institutes of Health

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Related topics

2 relations

Broader (2)

PeptidesRecombinant Proteins

Papers overview

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Highly Cited
2009
Highly Cited
2009
Myocardial Adeno-Associated Virus Serotype 6–&bgr;ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure
Background— The upregulation of G protein–coupled receptor kinase 2 in failing myocardium appears to contribute to dysfunctional… Expand
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2008
2008
Identification of Nogo as a novel indicator of heart failure.
Numerous genetically engineered animal models of heart failure (HF) exhibit multiple characteristics of human HF, including… Expand
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Highly Cited
2004
Highly Cited
2004
Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes*
In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat… Expand
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2004
2004
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
BACKGROUND Failing human myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR… Expand
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Highly Cited
2002
Highly Cited
2002
G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase*
A large number of studies have demonstrated co-purification or co-immunoprecipitation of receptors with G proteins. We have begun… Expand
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2002
2002
Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes.
  • A. Eckhart, W. Koch
  • Molecular therapy : the journal of the American…
  • 2002
    • Corpus ID: 36512544
The spontaneously hypertensive heart failure (SHHF) rat shares numerous functional and molecular characteristics of human heart… Expand
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Highly Cited
2001
Highly Cited
2001
Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase*
Recent evidence suggests that many signaling molecules localize in microdomains of the plasma membrane, particularly caveolae. In… Expand
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Highly Cited
2001
Highly Cited
2001
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased… Expand
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2001
2001
Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor
Background—Acute cardiac contractile dysfunction is common after cardiopulmonary bypass (CPB). A potential molecular mechanism is… Expand
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Highly Cited
2000
Highly Cited
2000
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR… Expand
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