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beta-adrenergic receptor kinase inhibitory peptide

Known as: betaARK1 inhibitor, betaARKct peptide, beta-adrenergic receptor kinase inhibitor 
National Institutes of Health

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2 relations

Broader (2)

PeptidesRecombinant Proteins

Papers overview

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Highly Cited
2009
Highly Cited
2009
Myocardial Adeno-Associated Virus Serotype 6–&bgr;ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure
Background— The upregulation of G protein–coupled receptor kinase 2 in failing myocardium appears to contribute to dysfunctional… 
Highly Cited
2004
Highly Cited
2004
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
BACKGROUND Failing human myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR… 
Highly Cited
2004
Highly Cited
2004
Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes*
In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat… 
Highly Cited
2004
Highly Cited
2004
G Protein–Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning
Abstract— The present study is designed to explore the role of G protein–coupled receptors (GPCRs) in the protection afforded by… 
Highly Cited
2003
Highly Cited
2003
Differential myocardial gene expression in the development and rescue of murine heart failure.
Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac… 
Highly Cited
2002
Highly Cited
2002
G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase*
A large number of studies have demonstrated co-purification or co-immunoprecipitation of receptors with G proteins. We have begun… 
Highly Cited
2001
Highly Cited
2001
Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase*
Recent evidence suggests that many signaling molecules localize in microdomains of the plasma membrane, particularly caveolae. In… 
Highly Cited
2001
Highly Cited
2001
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased… 
Highly Cited
2001
Highly Cited
2001
Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor
Background—Acute cardiac contractile dysfunction is common after cardiopulmonary bypass (CPB). A potential molecular mechanism is… 
Highly Cited
2000
Highly Cited
2000
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR… 
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