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beta-adrenergic receptor kinase inhibitory peptide
Known as:
betaARK1 inhibitor
, betaARKct peptide
, beta-adrenergic receptor kinase inhibitor
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Peptides
Recombinant Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Myocardial Adeno-Associated Virus Serotype 6–&bgr;ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure
G. Rengo
,
A. Lymperopoulos
,
+4 authors
W. Koch
Circulation
2009
Corpus ID: 152479
Background— The upregulation of G protein–coupled receptor kinase 2 in failing myocardium appears to contribute to dysfunctional…
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Highly Cited
2004
Highly Cited
2004
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
Matthew L. Williams
,
J. A. Hata
,
+5 authors
W. Koch
Circulation
2004
Corpus ID: 12935602
BACKGROUND Failing human myocardium is characterized by an attenuated contractile response to beta-adrenergic receptor (betaAR…
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Highly Cited
2004
Highly Cited
2004
Insulin-like Growth Factor-1 Induces an Inositol 1,4,5-Trisphosphate-dependent Increase in Nuclear and Cytosolic Calcium in Cultured Rat Cardiac Myocytes*
C. Ibarra
,
M. Estrada
,
+6 authors
S. Lavandero
Journal of Biological Chemistry
2004
Corpus ID: 9537409
In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat…
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Highly Cited
2004
Highly Cited
2004
G Protein–Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning
Haiyan Tong
,
H. Rockman
,
W. Koch
,
C. Steenbergen
,
E. Murphy
Circulation research
2004
Corpus ID: 13987270
Abstract— The present study is designed to explore the role of G protein–coupled receptors (GPCRs) in the protection afforded by…
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Highly Cited
2003
Highly Cited
2003
Differential myocardial gene expression in the development and rescue of murine heart failure.
B. Blaxall
,
R. Spang
,
H. Rockman
,
W. Koch
Physiological genomics
2003
Corpus ID: 478771
Numerous murine models of heart failure (HF) have been described, many of which develop progressive deterioration of cardiac…
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Highly Cited
2002
Highly Cited
2002
G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase*
N. Lavine
,
N. Éthier
,
+7 authors
H. V. Van Tol
The Journal of Biological Chemistry
2002
Corpus ID: 41217261
A large number of studies have demonstrated co-purification or co-immunoprecipitation of receptors with G proteins. We have begun…
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Highly Cited
2001
Highly Cited
2001
Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase*
R. Ostrom
,
C. Gregorian
,
R. Drenan
,
Y. Xiang
,
J. Regan
,
P. Insel
The Journal of Biological Chemistry
2001
Corpus ID: 28961372
Recent evidence suggests that many signaling molecules localize in microdomains of the plasma membrane, particularly caveolae. In…
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Highly Cited
2001
Highly Cited
2001
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
V. B. Harding
,
L. Jones
,
R. Lefkowitz
,
W. Koch
,
H. Rockman
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 19318984
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased…
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Highly Cited
2001
Highly Cited
2001
Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a &bgr;-Adrenergic Receptor Kinase Inhibitor
H. Tevaearai
,
A. Eckhart
,
K. Shotwell
,
K. Wilson
,
W. Koch
Circulation
2001
Corpus ID: 14766632
Background—Acute cardiac contractile dysfunction is common after cardiopulmonary bypass (CPB). A potential molecular mechanism is…
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Highly Cited
2000
Highly Cited
2000
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
D. C. White
,
J. A. Hata
,
A. Shah
,
D. Glower
,
R. Lefkowitz
,
W. Koch
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 42769932
When the heart fails, there is often a constellation of biochemical alterations of the beta-adrenergic receptor (betaAR…
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