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benzene metabolic process

Known as: benzene metabolism 
The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the… Expand
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Leukemia and Benzene
  • R. Snyder
  • International journal of environmental research…
  • 2012
    • Corpus ID: 5090902
Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the… Expand
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Highly Cited
2008
Highly Cited
2008
QM/MM modeling of benzene hydroxylation in human cytochrome P450 2C9.
The mechanism of benzene hydroxylation was investigated in the realistic enzyme environment of the human CYP 2C9 by using quantum… Expand
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Highly Cited
1990
Highly Cited
1990
Monoclonal antibody-directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes.
The contribution of cytochrome P450IA, P450IIB, P450IICII and P450IIEI to the oxidative metabolism of benzene, 7-ethoxyresorufin… Expand
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Highly Cited
1989
Highly Cited
1989
Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice.
To determine the effect of exposure concentration and the route of administration on benzene metabolism, male F344/N rats and… Expand
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Highly Cited
1989
Highly Cited
1989
A physiological model for simulation of benzene metabolism by rats and mice.
Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice are more… Expand
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Highly Cited
1989
Highly Cited
1989
The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites.
Studies were completed in F344/N rats and B6C3F1 mice to determine the effect of dose, dose rate, route of administration, and… Expand
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1989
1989
Immunochemical characterization of cytochrome P-450 isozymes responsible for benzene oxidation in the rat liver.
The contribution of cytochrome P-450 isozymes to benzene metabolism in liver microsomes from fed, fasted, pyrazole… Expand
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Highly Cited
1988
Highly Cited
1988
Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes.
Ethanol is known to exert a synergistic effect on the toxicity of benzene. In the present investigation it was found that benzene… Expand
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Highly Cited
1986
Highly Cited
1986
Formation of muconaldehyde, an open-ring metabolite of benzene, in mouse liver microsomes: an additional pathway for toxic metabolites.
It has been proposed that a ring-opened form may be responsible for the toxicity of benzene. The present studies demonstrate that… Expand
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Highly Cited
1973
Highly Cited
1973
Benzene metabolism in mouse liver microsomes.
Abstract Mouse liver microsomes metabolized benzene more rapidly than microsomes prepared from rat and rabbit liver. Treatment of… Expand
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