benzene metabolic process
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Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the… Expand The mechanism of benzene hydroxylation was investigated in the realistic enzyme environment of the human CYP 2C9 by using quantum… Expand Albumin adducts of benzene oxide (BO-Alb) and 1,4-benzoquinone (1,4-BQ-Alb) were investigated among 134 workers exposed to… Expand The contribution of cytochrome P450IA, P450IIB, P450IICII and P450IIEI to the oxidative metabolism of benzene, 7-ethoxyresorufin… Expand To determine the effect of exposure concentration and the route of administration on benzene metabolism, male F344/N rats and… Expand Studies were completed in F344/N rats and B6C3F1 mice to determine the effect of dose, dose rate, route of administration, and… Expand Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice are more… Expand Ethanol is known to exert a synergistic effect on the toxicity of benzene. In the present investigation it was found that benzene… Expand It has been proposed that a ring-opened form may be responsible for the toxicity of benzene. The present studies demonstrate that… Expand Abstract Mouse liver microsomes metabolized benzene more rapidly than microsomes prepared from rat and rabbit liver. Treatment of… Expand