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bendazac

Known as: 1-benzylindazole-3-oxyacetic acid, bendazolic acid, bindazac 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Anti-Inflammatory Agents, Non-SteroidalIndazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.
Drug-induced liver injury (DILI) is a significant consideration for drug development. Current preclinical DILI assessment relying… Expand
2010
2010
Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents.
Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c-d, 15c, 17c) showed very… Expand
1995
1995
Radical scavenger activity of bendazac, an anticataract non-steroidal anti-inflammatory agent.
Oxidative damage to lens components is associated with cataract formation and reactive oxygen species (ROS) overproduction at… Expand
1995
1995
Bendazac decreases in vitro glycation of human lens crystallins. Decrease of in vitro protein glycation by bendazac.
Bendazac has been used as an anti-cataractogenic drug. It has been reported that this acts by preventing protein denaturation. In… Expand
1994
1994
Ocular absorption and distribution of bendazac after topical administration to rabbits with different vehicles.
Ocular and systemic absorption of bendazac was investigated after topical administration to rabbits of 0.5% solutions of bendazac… Expand
1990
1990
Antioxidant characteristics of some potential anticataract agents. Studies of aspirin, paracetamol, and bendazac provide support for an oxidative component of cataract.
It is conceivable that drugs with anticataract potential possess antioxidant activity. Using defined chelating agents and… Expand
1988
1988
The major metabolite of bendazac inhibits the glycosylation of soluble lens proteins: a possible mechanism for a delay in cataractogenesis.
Glucose-6-phosphate and galactose react non-enzymically with lens proteins. The rates of these reactions are decreased by 5… Expand
1987
1987
The neutralization of hydroxyl radical by silibin, sorbinil and bendazac.
The compounds silibin, sorbinil and bendazac act as hydroxyl radical scavengers, when the hydroxyl radical is generated by the… Expand
1986
1986
Bendazac prevents cyanate binding to soluble lens proteins and cyanate-induced phase-separation opacities in vitro: a possible mechanism by which bendazac could delay cataract.
The reaction of lens proteins with cyanate (carbamylation) causes many changes seen in human cataract including disruption of the… Expand
1983
1983
Basic data supporting the use of the l-lysine salt of bendazac in cataract.
Bendazac, as such or in the form of its l-lysine salt, has a protective effect against lens protein denaturation both in vitro… Expand
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