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belactosin A

 
National Institutes of Health

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2014
2014
Rational scaffold hopping of a natural product belactosin A derivative was successfully achieved based on the pharmacophore model… Expand
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2014
2014
Proteasome inhibitors are currently a focus of increased attention as anticancer drug candidates. We recently performed… Expand
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2013
2013
The natural product belactosin A (1) with a trans-cyclopropane structure is a useful prototype compound for developing potent… Expand
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2013
2013
The belactosin A analog 2a, having the unnatural cis-cyclopropane structure instead of the trans-cyclopropane structure in… Expand
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2010
2010
An efficient and convenient methodology for the synthesis of the 3-(trans-2-aminocyclopropyl) alanine and 3-(trans-2… Expand
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2009
2009
The development of potent proteasome inhibitors based on the stereochemical diversity-oriented strategy using a conformationally… Expand
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2009
2009
The proteasome inhibitors are used as research tools to study of the ATP-dependent ubiquitin-proteasome system. Some of them are… Expand
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2008
2008
Belactosin A is a potent proteasome inhibitor isolated from Streptomyces metabolites. Here we show that a hydrophobic belactosin… Expand
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2008
2008
A series of chiral 2,3- and 3,4-methanoamino acid equivalents of stereochemical diversity were designed and synthesized from our… Expand
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2004
2004
[reaction: see text] Enantioselective total syntheses of belactosin A, belactosin C, and its homoanalogue have been accomplished… Expand
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