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bcl-x protein

Known as: BCL2L1, bcl-X Protein [Chemical/Ingredient], bcl2-Like 1 Protein 
A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS and is a regulatory subunit for PROTEIN PHOSPHATASE 1. Two… 
National Institutes of Health

Related topics

Related topics

14 relations

Narrower (4)

BCL-XL ProteinBCL-Xs proteinbcl-Xalpha Proteinbcl-Xbeta Protein
BCL2L1 geneIn BloodProcess of secretionagonists

Broader (1)

Proto-Oncogene Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions
Identification of effective combination therapies is critical to address the emergence of drug-resistant cancers, but direct… 
Highly Cited
2006
Highly Cited
2006
Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification
DNA amplifications and deletions frequently contribute to the development and progression of lung cancer. To identify such novel… 
Highly Cited
2000
Highly Cited
2000
The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).
The transcription factors of the Rel/NF-kappaB family are key regulators of immune and inflammatory responses and contribute to… 
Highly Cited
2000
Highly Cited
2000
The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat51
Studies assessing the role of Stat5 in the IL-2 proliferative signal have produced contradictory, and thus inconclusive, results… 
Highly Cited
1997
Highly Cited
1997
Evidence for the rapid onset of apoptosis in medial smooth muscle cells after balloon injury.
BACKGROUND Vascular myocyte apoptotic cell death has been reported in human atherectomy and endarterectomy specimens and for… 
Highly Cited
1996
Highly Cited
1996
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2…
It has been shown recently in China that arsenic trioxide (As2O3) is a very effective treatment for acute promyelocytic leukemia… 
Highly Cited
1996
Highly Cited
1996
Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL.
The molecular mechanism of cell death due to hypoxia has not been elucidated. Our recent observations that overexpression of the… 
Highly Cited
1995
Highly Cited
1995
Upregulation of bax protein levels in neurons following cerebral ischemia
The patterns of expression of the bcl-2, bax, and bci-X genes were examined immunohistochemically in neurons of the adult rat… 
Highly Cited
1995
Highly Cited
1995
Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and…
The loss of ovarian follicles through atresia, which accounts for greater than 99% of postnatal female germ cell depletion, is… 
Review
1995
Review
1995
Regulation of lymphocyte survival by the bcl-2 gene family.
The control of cell survival is of central importance in tissues with high cell turnover such as the lymphoid system, and its… 
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