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batracylin

Known as: 8-Aminoisoindolo(1,2-b)quinazolin-12(10H)-one, 8-aminoisoindolo(1,2-b)quinazolin-12(10H)one, DANIQUIDONE 
A water-insoluble heterocyclic amide with potential antineoplastic activity. Daniquidone inhibits topoisomerases I and II, thereby inhibiting DNA… 
National Institutes of Health

Related topics

Related topics

3 relations
DNA

Narrower (1)

NSC 320846

Broader (1)

Quinazolines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Comparative Metabolism of Batracylin (NSC 320846) and N-acetylbatracylin (NSC 611001) Using Human, Dog, and Rat Preparations In Vitro.
BACKGROUND Batracylin is a heterocyclic arylamine topoisomerase inhibitor with preclinical anticancer activity. Marked species… 
2014
2014
Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes.
A convenient procedure for the carbonylative synthesis of isoindoloquinazolinones has been developed. Using 1,2-dibromobenzenes… 
2007
2007
Batracylin, 8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one (NSC 320846), a dual inhibitor of DNA topoisomerases I and II: molecular mechanisms and γ-H2AX as a biomarker of DNA damage.
A172 Batracylin (8-aminoisoindolo [1,2-b]quinazolin-10(12H)-one; NSC320846) is an investigational clinical anticancer agent… 
2004
2004
Antitumor drug cross-resistance in vivo in a cisplatin-resistant murine P388 leukemia
SummarySince 1978, over 50 clinically useful antitumor drugs or new candidate antitumor agents have been evaluated in vivo… 
2004
2004
Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A
The heterocyclic amine, batracylin (BAT), is genotoxic and several lines of evidence suggest that acetylation is one step in the… 
1995
1995
The role of n-acetylation in the genotoxicity of the antitumor agent, batracylin.
1993
1993
A structure-activity relationship study of batracylin analogues.
A number of isoindolo[1,2-b]quinazolines and some benzo[4,5]isoquinolino[1,2-b]quinazolines as structural modification analogues… 
1989
1989
High-performance liquid chromatographic assay and preclinical pharmacologic studies with the experimental antitumor agent batracylin.
1988
1988
A new antitumour agent, batracylin, selected by a preclinical solid tumour model.
The antitumour efficacy of batracylin was investigated in vivo against murine tumours. The drug displayed an original spectrum of… 
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