batimastat

Known as: [4-(N-Hydroxyamino)-2R-isobutyl-3S-(thiophen-2-ylthiomethyl)-succinyl]-L-phenylalanine-N-methylamide, Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))-, (2R,3S)-N{4}-Hydroxy-N{1}-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide 
A synthetic hydroxamate with potential antineoplastic activity. Batimastat binds covalently to the zinc ion in the active site of matrix… (More)
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
This study investigated the functional interplay between vascular endothelial growth factor (VEGF) and metalloproteinases (MMPs… (More)
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Highly Cited
2001
Highly Cited
2001
Overexpression of matrix metalloproteinases (MMPs) facilitates tumor cell invasion. Synthetic MMP inhibitors such as batimastat… (More)
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Highly Cited
2001
Highly Cited
2001
HER2 is a ligand-less tyrosine kinase receptor of the ErbB family that is frequently overexpressed in breast cancer. It undergoes… (More)
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Highly Cited
2001
Highly Cited
2001
Bleomycin-induced pulmonary fibrosis is known to be associated with the increased activity of two gelatinases, matrix… (More)
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Highly Cited
2000
Highly Cited
2000
It has been shown recently that matrix metalloproteinases (MMPs) are elevated after cerebral ischemia. In the current study, we… (More)
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Highly Cited
1999
Highly Cited
1999
Cross-communication between different signalling systems allows the integration of the great diversity of stimuli that a cell… (More)
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1998
1998
A method for culturing explants of lamellar hoof was developed to investigate the process of lamellar separation that occurs in… (More)
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Highly Cited
1996
Highly Cited
1996
We examined the effects of the synthetic matrix metalloproteinase inhibitor batimastat (BB-94) on lung colonization and… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The importance of matrix metalloproteinases in angiogenesis, tumor growth, and metastasis is well known. However… (More)
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Highly Cited
1994
Highly Cited
1994
Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors. This role was investigated in an… (More)
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