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basimglurant

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Mood disorders represent the largest cause of disability worldwide. The monoaminergic deficiency hypothesis, which has dominated… Expand
Review
2017
Review
2017
Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is implicated in mood disorders such as… Expand
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2017
2017
Basimglurant, a novel mGlu5-negative allosteric modulator under development for the treatment of major depressive disorder, is… Expand
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2017
2017
Alzheimer's disease amyloid-β (Aβ) oligomers are synaptotoxic, inappropriately increasing extracellular glutamate concentration… Expand
Highly Cited
2016
Highly Cited
2016
IMPORTANCE Antagonism of the postsynaptic metabotropic glutamate subtype 5 receptor is a novel approach to modulate glutamatergic… Expand
Review
2016
Review
2016
Chronic stress-related psychiatric conditions such as anxiety, depression, and alcohol abuse are an enormous public health… Expand
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Highly Cited
2015
Highly Cited
2015
Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is… Expand
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Highly Cited
2015
Highly Cited
2015
Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential for the treatment of… Expand
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2015
2015
Introduction: Metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAM) such as 2-Methyl-6-(phenylethynyl… Expand
2015
2015
Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is… Expand
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  • figure 3