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Mood disorders represent the largest cause of disability worldwide. The monoaminergic deficiency hypothesis, which has dominated… Expand Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is implicated in mood disorders such as… Expand Basimglurant, a novel mGlu5-negative allosteric modulator under development for the treatment of major depressive disorder, is… Expand Alzheimer's disease amyloid-β (Aβ) oligomers are synaptotoxic, inappropriately increasing extracellular glutamate concentration… Expand IMPORTANCE
Antagonism of the postsynaptic metabotropic glutamate subtype 5 receptor is a novel approach to modulate glutamatergic… Expand Chronic stress-related psychiatric conditions such as anxiety, depression, and alcohol abuse are an enormous public health… Expand Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is… Expand Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have potential for the treatment of… Expand Introduction: Metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAM) such as 2-Methyl-6-(phenylethynyl… Expand Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is… Expand