aziridinomitosene

 
National Institutes of Health

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Aziridines

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2015
2015
Investigations into Aziridinomitosene DNA-Protein Crosslinking in Human Cancer Cells
 
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2012
2012
Reactivity of aziridinomitosene derivatives related to FK317 in the presence of protic nucleophiles.
The syntheses and reactivity of N-TBDPS and N-trityl protected derivatives of an aziridinomitosene corresponding to FK317 are… (More)
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2012
2012
Probing for Aziridinomitosene-Induced Cytotoxic Footprints
 
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2011
2011
First synthesis of an aziridinyl fused pyrrolo[1,2-a]benzimidazole and toxicity evaluation towards normal and breast cancer cell lines.
Anionic aromatic ipso-substitution has allowed an aziridine ring to be fused onto pyrrolo[1,2-a]benzimidazole. This diazole… (More)
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2010
2010
Reaction of reductively activated mitomycin C with aqueous bicarbonate: Isolation and characterization of an oxazolidinone derivative of cis-1-hydroxy-2,7-diaminomitosene.
The reductive activation of mitomycin C in aqueous bicarbonate buffer resulted in the formation of a previously unknown compound… (More)
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2010
2010
Cross-linking of dithiols by mitomycin C.
Upon reduction, the antitumor drug mitomycin C undergoes a cascade of reactions to give a bis-electrophile that alkylates… (More)
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2009
2009
Reductive activation of mitomycin C by thiols: kinetics, mechanism, and biological implications.
The clinically used antitumor antibiotic mitomycin C requires a reductive activation to be converted to a bis-electrophile that… (More)
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2005
2005
Sequence-specific DNA interstrand cross-linking by an aziridinomitosene in the absence of exogenous reductant.
The aziridinomitosene derivative (1S,2S)-6-desmethyl(methylaziridino)mitosene (4) was shown to alkylate plasmid DNA at pH 7.4 in… (More)
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1989
1989
DNA cross-linking by intermediates in the mitomycin activation cascade.
We have assayed the cross-linking of oligonucleotides containing repeated mitomycin-reactive CpG sites in order to assess the… (More)
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1985
1985
A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes.
Two mechanisms proposed for the acid-catalyzed conversions of mitomycins into mitosenes were investigated by deuterium… (More)
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