aziridinomitosene

 
National Institutes of Health

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2012
2012
The syntheses and reactivity of N-TBDPS and N-trityl protected derivatives of an aziridinomitosene corresponding to FK317 are… (More)
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2011
2011
Anionic aromatic ipso-substitution has allowed an aziridine ring to be fused onto pyrrolo[1,2-a]benzimidazole. This diazole… (More)
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2010
2010
The reductive activation of mitomycin C in aqueous bicarbonate buffer resulted in the formation of a previously unknown compound… (More)
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2010
2010
Upon reduction, the antitumor drug mitomycin C undergoes a cascade of reactions to give a bis-electrophile that alkylates… (More)
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2009
2009
The clinically used antitumor antibiotic mitomycin C requires a reductive activation to be converted to a bis-electrophile that… (More)
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2005
2005
The aziridinomitosene derivative (1S,2S)-6-desmethyl(methylaziridino)mitosene (4) was shown to alkylate plasmid DNA at pH 7.4 in… (More)
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1989
1989
We have assayed the cross-linking of oligonucleotides containing repeated mitomycin-reactive CpG sites in order to assess the… (More)
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1985
1985
Two mechanisms proposed for the acid-catalyzed conversions of mitomycins into mitosenes were investigated by deuterium… (More)
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