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azinomycin B

Known as: 1-Naphthalenecarboxylic acid, 3-methoxy-5-methyl-, 2-((1-(3-(acetyloxy)-4-hydroxy-1-azabicyclo(3.1.0)hex-2-ylidene)-2-((1-(hydroxymethylene)-2-oxopropyl)amino)-2-oxoethyl)amino)-1-(2-methyloxiranyl)-2-oxoethyl ester 
National Institutes of Health

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Broader (2)

NaphthalenesPeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Transketolase Activity in the Formation of the Azinomycin Azabicycle Moiety.
The biosynthesis of the azinomycins involves the conversion of glutamic acid to an aziridino[1,2-a]pyrrolidine moiety, which… 
2017
2017
Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding.
To explore the utility of the azinomycin B chromophore as a platform for the development of major-groove binding small molecules… 
2013
2013
Reversal of substrate specificity of CMP N-glycosidase to dCMP and crystallographic studies on bacimethrin and azinomycin B biosynthesis enzymes
2012
2012
Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study
AbstractAzinomycin B—a well-known antitumor drug—forms cross-links with DNA through alkylation of purine bases and blocks tumor… 
2011
2011
Characterization of AziR, a resistance protein of the DNA cross-linking agent azinomycin B.
A protein identified from the Streptomyces sahachiroi genome exhibits a protective effect against the DNA alkylator azinomycin B… 
2007
2007
Dependence of DNA sequence selectivity and cell cytotoxicity on azinomycin A and B epoxyamide stereochemistry.
Evaluation of the importance of C18/C19 stereochemistry of azinomycin A/B epoxyamide partial structures with respect to DNA… 
Review
2006
Review
2006
Azinomycin A and B Epoxyamide Stereochemistry: Relevance to DNA Sequence Selectivity
.................................................................................................. Dedication… 
2005
2005
Molecular Modeling of DNA Cross-linking Analogues Based on the Azinomycin Scaffold
In this work, we present molecular modeling studies carried out using six DNA sequences and six azinomycin analogues, including… 
2004
2004
The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B.
13C-labelled acetate efficiently labels the antitumour natural product azinomycin B, revealing a polyketide origin for the… 
2002
2002
DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivity.
A new set of charges specifically developed for biologically relevant N7-alkylated purine adducts have been implemented in the… 
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