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asperlicin

Known as: (S-(2alpha,9beta,9(R*),9alpha,beta))-6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, Quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, 6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)-, (2S-(2alpha,9beta,9(R*),9abeta))- 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

BenzodiazepinonesHormone Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Synthesis and evaluation of asperlicin analogues as non-peptidal cholecystokinin-antagonists.
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step… Expand
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1989
1989
Cholecystokinin and gastrin peptides stimulate ODC activity in a rat pancreatic cell line.
Recent studies have demonstrated that cholecystokinin (CCK) receptors are heterologous in peripheral tissues and in the central… Expand
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1989
1989
Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo.
The present experiments evaluate in vivo effects of recently described cholecystokinin (CCK) receptor antagonists on rat… Expand
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1988
1988
Asperlicin, a nonpeptidal cholecystokinin receptor antagonist, attenuates sodium taurocholate-induced acute pancreatitis in rats.
Asperlicin (ASP), a new, nonpeptidal cholecystokinin (CCK) receptor antagonist isolated from the fungus Aspergillus alliaceus… Expand
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1988
1988
On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that… Expand
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1987
1987
Asperlicin: a unique nonpeptide cholecystokinin antagonist.
The lack of a potent and specific cholecystokinin (CCK) receptor antagonist has greatly hampered studies of the role of CCK in… Expand
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1987
1987
Characterization of gastrin receptors on guinea pig pancreatic acini.
Recent studies have demonstrated gastrin receptors in some pancreatic tumors and that gastrin is a potent stimulant of pancreatic… Expand
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1986
1986
Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility.
Seventeen analogues of the selective, competitive cholecystokinin (CCK) antagonist asperlicin 1 were prepared. These compounds… Expand
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Highly Cited
1985
Highly Cited
1985
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus… Expand
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1985
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties.
The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is… Expand
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