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asperlicin

Known as: (S-(2alpha,9beta,9(R*),9alpha,beta))-6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, Quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, 6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)-, (2S-(2alpha,9beta,9(R*),9abeta))- 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

BenzodiazepinonesHormone Antagonists

Papers overview

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Highly Cited
2006
Highly Cited
2006
CuI-Catalyzed tandem intramolecular amidation using gem-dibromovinyl systems.
[reaction: see text] Imidazoindolones are present as the key structural motif in the family of antifungals, fumiquinazolines, and… Expand
2001
2001
Synthesis and evaluation of asperlicin analogues as non-peptidal cholecystokinin-antagonists.
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step… Expand
Highly Cited
1993
Highly Cited
1993
5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners.
A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in… Expand
1988
1988
On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that… Expand
1988
1988
Asperlicin, A Nonpeptidal Cholecystokinin Receptor Antagonist, Attenuates Sodium Taurocholate‐Induced Acute Pancreatitis in Rats
Asperlicin (ASP), a new, nonpeptidal cholecystokinin (CCK) receptor antagonist isolated from the fungus Aspergillus alliacerrs… Expand
1987
1987
Asperlicin antagonizes stimulatory effects of cholecystokinin on isolated islets.
Asperlicin, a product derived from the fungus Aspergillus alliaceus, antagonized the multiple stimulatory effects of… Expand
1986
1986
Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility.
Seventeen analogues of the selective, competitive cholecystokinin (CCK) antagonist asperlicin 1 were prepared. These compounds… Expand
Highly Cited
1985
Highly Cited
1985
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus… Expand
Highly Cited
1985
Highly Cited
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties.
The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is… Expand
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1985
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Structure elucidation.
Asperlicin (1, C31H29N5O4) is a novel cholecystokinin antagonist produced by Aspergillus alliaceus. The structure of asperlicin… Expand
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