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asperlicin
Known as:
(S-(2alpha,9beta,9(R*),9alpha,beta))-6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione
, Quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, 6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)-, (2S-(2alpha,9beta,9(R*),9abeta))-
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Benzodiazepinones
Hormone Antagonists
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Synthesis and evaluation of asperlicin analogues as non-peptidal cholecystokinin-antagonists.
E. Lattmann
,
D. Billington
,
D. Poyner
,
S. B. Howitt
,
M. Offel
Drug Design and Discovery
2001
Corpus ID: 27886388
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step…
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Review
1998
Review
1998
CCK receptor antagonists.
J. Dunlop
General Pharmacology
1998
Corpus ID: 22579558
Highly Cited
1993
Highly Cited
1993
5-N-acetylardeemin, a novel heterocyclic compound which reverses multiple drug resistance in tumor cells. II. Isolation and elucidation of the structure of 5-N-acetylardeemin and two congeners.
J. Hochlowski
,
M. Mullally
,
S. Spanton
,
D. Whittern
,
P. Hill
,
J. McAlpine
Journal of antibiotics (Tokyo. )
1993
Corpus ID: 31714412
A family of novel compounds has been detected and isolated following an assay for the attenuation of multiple drug resistance in…
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1988
1988
On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
D. Houck
,
J. Ondeyka
,
D. Zink
,
E. Inamine
,
M. Goetz
,
O. Hensens
Journal of antibiotics (Tokyo. )
1988
Corpus ID: 978934
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that…
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1986
1986
Characterization of [3H]pentagastrin binding in guinea pig gastric glands--an alternative convenient ligand for receptor binding assay.
R. Chang
,
V. Lotti
,
M. E. Keegan
,
K. Kunkel
Biochemical and Biophysical Research…
1986
Corpus ID: 40070213
1986
1986
A new simple mouse model for the in vivo evaluation of cholecystokinin (CCK) antagonists: comparative potencies and durations of action of nonpeptide antagonists.
V. J. Lotti
,
D. Cerino
,
P. Kling
,
R. S. Change
Life Science
1986
Corpus ID: 1279148
1986
1986
Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility.
M. Bock
,
R. M. Dipardo
,
+7 authors
V. J. Lotti
Journal of Medicinal Chemistry
1986
Corpus ID: 38122788
Seventeen analogues of the selective, competitive cholecystokinin (CCK) antagonist asperlicin 1 were prepared. These compounds…
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Highly Cited
1985
Highly Cited
1985
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
R. Chang
,
V. Lotti
,
+7 authors
O. Hensens
Science
1985
Corpus ID: 27856527
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus…
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Highly Cited
1985
Highly Cited
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties.
M. Goetz
,
M. López
,
R. Monaghan
,
R. Chang
,
V. Lotti
,
T. B. Chen
Journal of antibiotics (Tokyo. )
1985
Corpus ID: 764375
The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is…
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1985
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Structure elucidation.
J. Liesch
,
O. Hensens
,
J. Springer
,
R. Chang
,
V. Lotti
Journal of antibiotics (Tokyo. )
1985
Corpus ID: 32395477
Asperlicin (1, C31H29N5O4) is a novel cholecystokinin antagonist produced by Aspergillus alliaceus. The structure of asperlicin…
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