FAQ

asperlicin

Known as: (S-(2alpha,9beta,9(R*),9alpha,beta))-6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, Quinazolino(3,2-a)(1,4)benzodiazepine-5,13-dione, 6,7-dihydro-7-((2,3,9,9a-tetrahydro-9-hydroxy-2-(2-methylpropyl)-3-oxo-1H-imidazo(1,2-a)indol-9-yl)methyl)-, (2S-(2alpha,9beta,9(R*),9abeta))- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2017
02419852017

Related topics

Related topics

2 relations

Broader (2)

BenzodiazepinonesHormone Antagonists

Related mentions per year

Related mentions per year

1951-2018
1960198020002020
asperlicin
Hormone Antagonists
Benzodiazepinones

Papers overview

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2012
2012
Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.
Members of the asperlicin family of fungal metabolites produced by Aspergillus alliaceus are known potent CCK(A) antagonists… (More)
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2001
2001
Synthesis and evaluation of asperlicin analogues as non-peptidal cholecystokinin-antagonists.
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step… (More)
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1989
1989
Cholecystokinin and gastrin peptides stimulate ODC activity in a rat pancreatic cell line.
Recent studies have demonstrated that cholecystokinin (CCK) receptors are heterologous in peripheral tissues and in the central… (More)
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1988
1988
On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that… (More)
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1987
1987
Asperlicin: a unique nonpeptide cholecystokinin antagonist.
The lack of a potent and specific cholecystokinin (CCK) receptor antagonist has greatly hampered studies of the role of CCK in… (More)
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1986
1986
Cholecystokinin antagonists. Synthesis of asperlicin analogues with improved potency and water solubility.
Seventeen analogues of the selective, competitive cholecystokinin (CCK) antagonist asperlicin 1 were prepared. These compounds… (More)
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1986
1986
Evidence that cholecystokinin octapeptide (CCK-8) acts as a potent, full agonist on gastrin receptors for acid secretion in the isolated mouse stomach: lack of antagonism by the specific CCK…
Cholecystokinin octapeptide (CCK-8) (EC50 = 5 nM) was considerably more potent than pentagastrin (EC50 = 161 nM) in stimulating… (More)
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1985
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Structure elucidation.
Asperlicin (1, C31H29N5O4) is a novel cholecystokinin antagonist produced by Aspergillus alliaceus. The structure of asperlicin… (More)
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1985
1985
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus… (More)
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1985
1985
Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties.
The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is… (More)
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