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aristolochic acid II

Known as: 6-nitrophenanthro(3,4-d)-3-dioxole-5-carboxylic acid 
 
National Institutes of Health

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Aristolochic Acids

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2001
2001
Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR.
The carcinogenic plant extract aristolochic acid (AA) is thought to be the major causative agent in the development of urothelial… Expand
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Highly Cited
1997
Highly Cited
1997
32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy.
Recently, we reported that aristolochic acid (AA) a naturally occurring nephrotoxin and carcinogen is implicated in a unique type… Expand
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1997
1997
Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling: evidence for reductive activation by peroxidases.
Aristolochic acid I (AAI) and aristolochic acid II (AAII), the two major components of the carcinogenic plant extract… Expand
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1994
1994
Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures.
We report the analysis of DNA adducts in the target organ (forestomach) of male Sprague-Dawley rats treated orally with two doses… Expand
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1991
1991
Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice.
The plant extract aristolochic acid, which consists mainly of aristolochic acid I (AAI) and aristolochic acid II (AAII), induces… Expand
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1991
1991
N6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen.
Aristolochic acid II (AAII), one of the major components of the carcinogenic plant extract aristolochic acid, is known to be… Expand
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1990
1990
32P-postlabelling analysis of the DNA adducts formed by aristolochic acid I and II.
We report the quantitation of DNA adducts in target and nontarget organs of male Wistar rats treated orally with five daily doses… Expand
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1988
1988
DNA adduct formation of aristolochic acid I and II in vitro and in vivo.
Aristolochic acid I (AA I) and aristolochic acid II (AA II), the two main ingredients of the carcinogenic plant extract… Expand
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1987
1987
Studies on the metabolism of aristolochic acids I and II.
1. After oral administration of aristolochic acid I (AAI) and aristolochic acid II (AAII) to rats, the following metabolites were… Expand
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1986
1986
Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver.
The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I… Expand
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