antisense therapy

Known as: Antisense, Antisense Oligonucleotide Therapy 
Treatment with antisense oligonucleotides. These are small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the cell's… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Oligonucleotides (oligos) have been under clinical development for approximately the past 30 years, beginning with antisense… (More)
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Review
2017
Review
2017
Recent studies have led to a greater appreciation of the diverse roles RNAs play in maintaining normal cellular function and how… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Duchenne's muscular dystrophy is associated with severe, progressive muscle weakness and typically leads to death… (More)
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Highly Cited
2006
Highly Cited
2006
Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… (More)
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Highly Cited
2003
Highly Cited
2003
The current challenge, now that two plant genomes have been sequenced, is to assign a function to the increasing number of… (More)
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Highly Cited
2002
Highly Cited
2002
Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of RNA interference (RNAi). Here, we… (More)
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Highly Cited
1999
Highly Cited
1999
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence-specific defense mechanism that can target both cellular and… (More)
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Highly Cited
1998
Highly Cited
1998
Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an… (More)
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Review
1995
Review
1995
The collagen superfamily of proteins now contains at least 19 proteins formally defined as collagens and an additional ten… (More)
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Highly Cited
1993
Highly Cited
1993
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by… (More)
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