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annamycin

Known as: 2'-iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin, 5,12-naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-l-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S-cis)- 
A lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA… Expand
National Institutes of Health

Papers overview

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2004
2004
Annamycin (Ann) is a lipophilic, non-cross resistant anthracycline antibiotic that is easily amenable to formulation in a wide… Expand
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1997
1997
Annamycin (Ann) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR‐I both in vitro and in vivo… Expand
1996
1996
A major factor in limiting the efficacy of anthracyclines is overexpression of the MDR1-encoded p-glycoprotein (p-gp). A new… Expand
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Review
1996
Review
1996
  • K. Wasan
  • Journal of pharmacological and toxicological…
  • 1996
  • Corpus ID: 46737328
The maximum tolerated dose and pharmacokinetics of a drug is usually determined in healthy human volunteers and animals. This… Expand
1995
1995
Annamycin (Ann) is a non‐cross‐resistant lipophilic anthracy‐cline antibiotic optimally suited for liposome delivery. We studied… Expand
1995
1995
Annamycin (Ann) is a new lipophilic anthracycline antibiotic with a marked ability to circumvent typical multidrug resistance… Expand
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Highly Cited
1994
Highly Cited
1994
The lipophilic anthracycline antibiotic annamycin (Ann) was entrapped in liposomes of different size [median diameter: 1.64… Expand
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Highly Cited
1993
Highly Cited
1993
The effect of the topoisomerase II inhibitor doxorubicin and its non-cross-resistant analogue annamycin on DNA degradation and… Expand
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1993
1993
Annamycin (AN) is an anthracycline antibiotic with high affinity for lipid membranes which is being developed for clinical… Expand
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1990
1990
We evaluated the entrapment of 21 different water-insoluble aglycones or anthracycline antibiotics in multilamellar liposomes… Expand