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annamycin liposomal

Known as: liposomal annamycin 
A liposome-encapsulated form of the semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and… Expand
National Institutes of Health

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annamycin

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2013
2013
Phase I/II trial of nanomolecular liposomal annamycin in adult patients with relapsed/refractory acute lymphoblastic leukemia.
BACKGROUND Treatment options for relapsed/refractory ALL in adult patients remain challenging. Annamycin is a highly lipophilic… Expand
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2012
2012
Treatment of Acute Lymphoblastic Leukaemia
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
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2009
2009
Phase I study results of nanomolecular liposomal annamycin in refractory ALL.
7066 Background: There continues to be no effective second-line therapy for refractory AML or ALL and the cure rate with current… Expand
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Review
2007
Review
2007
Treatment of acute lymphoblastic leukaemia : a new era.
Acute lymphocytic leukaemia (ALL) is a heterogeneous group of disorders that result from the clonal proliferation and expansion… Expand
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2002
2002
Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer
Abstract. Liposomal annamycin (L-AN) has shown antitumor activity in preclinical studies. It may selectively target tumors and… Expand
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2000
2000
Phase I study of liposomal annamycin
Abstract Annamycin is a highly lipophilic anthracycline with the ability to bypass the MDR-1 mechanism of cellular drug… Expand
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1997
1997
Modifications in high-density lipoprotein lipid composition and structure alter the plasma distribution of free and liposomal annamycin.
Recent studies have shown that changes in lipoprotein cholesterol and triglyceride concentration alters the plasma distribution… Expand
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1997
1997
Blood and plasma lipoprotein distribution and gender differences in the plasma pharmacokinetics of lipid-associated annamycin.
The objectives of this study were to determine the lipoprotein distribution of unbound annamycin and liposomal annamycin within… Expand
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1996
1996
Lyophilized preliposomal formulation of the non-cross-resistant anthracycline annamycin: effect of surfactant on liposome formation, stability and size
Abstract We report a method of preparing a submicron and stable liposome formulation of the non-cross-resistant anthracycline… Expand
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1995
1995
Distribution of free and liposomal annamycin within human plasma is regulated by plasma triglyceride concentrations but not by lipid transfer protein.
Annamycin (Ann) is a lipophilic and non-cross-resistant anthracycline antibiotic currently in clinical development as a liposomal… Expand
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