anidulafungin

Known as: Anidulafungine, Anidulafungina, (4R,5R)-4,5-Dihydroxy-N²-[[4''-(pentyloxy)-p-terphenyl-4-yl]carbonyl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6->1)-peptide 
A cyclic lipopeptide echinocandin derivative with antifungal activity. Anidulafungin inhibits 1,3 beta-D-glucan synthase, an enzyme involved in… (More)
National Institutes of Health

Papers overview

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2013
2013
OBJECTIVES Azole resistance is an emerging problem in the treatment of Aspergillus fumigatus infections. Combination therapy may… (More)
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Highly Cited
2008
Highly Cited
2008
The echinocandins are being used increasingly as therapy for invasive candidiasis. Prospective sentinel surveillance for the… (More)
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Highly Cited
2008
Highly Cited
2008
Highly Cited
2008
The CLSI Antifungal Subcommittee followed the M23-A2 "blueprint" to develop interpretive MIC breakpoints for anidulafungin… (More)
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Highly Cited
2008
Highly Cited
2008
Multiple in vivo studies have characterized the pharmacodynamics of drugs from the triazole and polyene antifungal drug classes… (More)
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2007
Highly Cited
2007
Two open-label studies assessed the effects of hepatic and renal impairment on anidulafungin pharmacokinetics. A single 50-mg… (More)
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2007
2007
BACKGROUND Anidulafungin, a new echinocandin, has potent activity against candida species. We compared anidulafungin with… (More)
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Highly Cited
2005
Highly Cited
2005
Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp. We assessed the in vitro activity of… (More)
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2005
2005
There is considerable interest in combining echinocandin and triazole antifungal agents for treatment of invasive fungal… (More)
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Highly Cited
2004
Highly Cited
2004
The objective of this analysis was to describe the pharmacokinetic characteristics of anidulafungin in patients with serious… (More)
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