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amotosalen hydrochloride

The hydrochloride salt form of amotosalen, a synthetic psoralen and light-activated DNA, RNA crosslinking agent, with protective activity against… Expand
National Institutes of Health

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amotosalen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Pathogen‐reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola‐specific neutralizing antibodies
Ebola virus disease is a public health emergency of international concern, and enormous efforts are being made in the development… Expand
2015
2015
Quantitative analysis of plasma proteins in whole blood-derived fresh frozen plasma prepared with three pathogen reduction technologies.
Several plasma pathogen reduction technologies (PRT) are currently available. We evaluated three plasma PRT processes: Cerus… Expand
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Highly Cited
2008
Highly Cited
2008
Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation.
Upon exposure to UVA light, psoralens can induce DNA interstrand cross-links (ICLs), which can block DNA replication and… Expand
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Review
2006
Review
2006
Risks of fresh frozen plasma and platelets.
Both fresh frozen plasma (FFP) and platelets are heavily used in massive transfusion. Although FFP can partially correct abnormal… Expand
2005
2005
Coagulation factor levels in cryosupernatant prepared from plasma treated with amotosalen hydrochloride (S‐59) and ultraviolet A light
BACKGROUND: The standard treatment for thrombotic thrombocytopenic purpura (TTP) is plasma exchange with fresh‐frozen plasma (FFP… Expand
2004
2004
Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model
BACKGROUND:  A photochemical treatment (PCT) process utilizing amotosalen hydrochloride and long wavelength UVA light has been… Expand
Highly Cited
2002
Highly Cited
2002
Pharmacokinetic study of FFP photochemically treated with amotosalen (S‐59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin
BACKGROUND : To date, no clinical trials have characterized FFP infusion efficacy, and infusion still carries infectious risk… Expand
Review
2001
Review
2001
Fundamentals of the psoralen-based Helinx technology for inactivation of infectious pathogens and leukocytes in platelets and plasma.
Psoralens plus ultraviolet A (UVA) light inactivate viruses and bacteria as well as leukocytes. A system employing the synthetic… Expand
Review
2001
Review
2001
Prevention of transfusion-associated graft-versus-host disease by inactivation of T cells in platelet components.
  • N. Luban
  • Seminars in hematology
  • 2001
    • Corpus ID: 29604121
Patients with hematological malignancies and infants with congenital immunodeficiencies who received blood are two of many… Expand
Review
2001
Review
2001
Inactivation of cytomegalovirus in platelet concentrates using Helinx technology.
  • L. Lin
  • Seminars in hematology
  • 2001
    • Corpus ID: 25911405
Cytomegalovirus (CMV) infection in immunocompromised patients may result in severe morbidity and mortality. The standard of care… Expand
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