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amotosalen hydrochloride

The hydrochloride salt form of amotosalen, a synthetic psoralen and light-activated DNA, RNA crosslinking agent, with protective activity against… Expand
National Institutes of Health

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amotosalen

Papers overview

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2016
2016
Composition of growth factors and cytokines in lysates obtained from fresh versus stored pathogen-inactivated platelet units.
BACKGROUND Platelet lysate is a readily available source of growth factors, and other mediators, which has been used in a variety… Expand
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2016
2016
Pathogen-reduced Ebola virus convalescent plasma: first steps towards standardization of manufacturing and quality control including assessment of Ebola-specific neutralizing antibodies.
BACKGROUND Ebola virus disease is a public health emergency of international concern, and enormous efforts are being made in the… Expand
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2008
2008
Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation.
Upon exposure to UVA light, psoralens can induce DNA interstrand cross-links (ICLs), which can block DNA replication and… Expand
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2005
2005
Coagulation factor levels in cryosupernatant prepared from plasma treated with amotosalen hydrochloride (S-59) and ultraviolet A light.
BACKGROUND The standard treatment for thrombotic thrombocytopenic purpura (TTP) is plasma exchange with fresh-frozen plasma (FFP… Expand
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2004
2004
Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion model.
BACKGROUND A photochemical treatment (PCT) process utilizing amotosalen hydrochloride and long wavelength UVA light has been… Expand
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2003
2003
Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59.
  • BioDrugs : clinical immunotherapeutics…
  • 2003
    • Corpus ID: 195690324
Adis CommentsCerus Corporation is developing a variety of pathogen-inactivation systems, based on its Helinx technology. Three of… Expand
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2002
2002
Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin.
BACKGROUND To date, no clinical trials have characterized FFP infusion efficacy, and infusion still carries infectious risk. This… Expand
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Review
2001
Review
2001
Fundamentals of the psoralen-based Helinx technology for inactivation of infectious pathogens and leukocytes in platelets and plasma.
Psoralens plus ultraviolet A (UVA) light inactivate viruses and bacteria as well as leukocytes. A system employing the synthetic… Expand
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Review
2001
Review
2001
Inactivation of cytomegalovirus in platelet concentrates using Helinx technology.
  • Lily Lin
  • Seminars in hematology
  • 2001
    • Corpus ID: 25911405
Cytomegalovirus (CMV) infection in immunocompromised patients may result in severe morbidity and mortality. The standard of care… Expand
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Review
2001
Review
2001
Prevention of transfusion-associated graft-versus-host disease by inactivation of T cells in platelet components.
Patients with hematological malignancies and infants with congenital immunodeficiencies who received blood are two of many… Expand
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