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amorpha-4,11-diene

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World… Expand
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Highly Cited
2009
Highly Cited
2009
Background Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective… Expand
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Highly Cited
2009
Highly Cited
2009
The introduction or creation of metabolic pathways in microbial hosts has allowed for the production of complex chemicals of… Expand
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Highly Cited
2006
Highly Cited
2006
Malaria is a global health problem that threatens 300–500 million people and kills more than one million people annually. Disease… Expand
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Highly Cited
2006
Highly Cited
2006
Reconstructing synthetic metabolic pathways in microbes holds great promise for the production of pharmaceuticals in large-scale… Expand
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Highly Cited
2003
Highly Cited
2003
Isoprenoids are the most numerous and structurally diverse family of natural products. Terpenoids, a class of isoprenoids often… Expand
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Highly Cited
2001
Highly Cited
2001
Abstract. The sesquiterpenoid artemisinin, isolated from the plant Artemisia annua L., and its semi-synthetic derivatives are a… Expand
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Highly Cited
2000
Highly Cited
2000
In plants, sesquiterpenes of different structural types are biosynthesized from the isoprenoid intermediate farnesyl diphosphate… Expand
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Highly Cited
2000
Highly Cited
2000
Artemisia annua, an indigenous plant to Korea, contains an antimalarial sesquiterpene, artemisinin. The first committed step of… Expand
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Highly Cited
1999
Highly Cited
1999
The endoperoxide sesquiterpene lactone artemisinin and its derivatives are a promising new group of drugs against malaria… Expand
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