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amocarzine

Known as: 4-nitro-4'-(N-methyl)piperazinyl thiocarbonylidodiphenylamine, Phenthiourezine, phenithiourezine 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

AnthelminticsFilaricidesPiperazines

Narrower (1)

CGP 6140

Papers overview

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Highly Cited
2006
Highly Cited
2006
Onchocerca parasites and Wolbachia endosymbionts: evaluation of a spectrum of antibiotic types for activity against Onchocerca gutturosa in vitro
Background The filarial parasites of major importance in humans contain the symbiotic bacterium Wolbachia and recent studies have… Expand
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2006
2006
Antifilarial activity in vitro of polycarpol and 3-O-acetyl aleuritolic acid from cameroonian medicinal plants against Onchocerca gutturosa
Previous results have revealed the antifilarial activities of crude extracts and pure compounds from some Cameroonian medicinal… Expand
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1998
1998
Immunoelectron microscopic evidence for release of eosinophil granule matrix protein onto microfilariae of Onchocerca volvulus in the skin after exposure to amocarzine
Abstract The involvement of eosinophils in the host reaction to microfilariae (mf) of Onchocerca volvulus was studied by… Expand
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1997
1997
The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment.
The hundred men from a forest area of Ghana, without vector control or ivermectin distribution, were randomized to receive a… Expand
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1997
1997
The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment.
One hundred men from a forest area of Ghana, without vector control or ivermectin distribution, were randomized to receive a… Expand
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Highly Cited
1996
Highly Cited
1996
The economic burden of global blindness: a price too high!
The World Health Organisation defines blindness as a best corrected visual acuity of less than 3/60.1 Using this definition it is… Expand
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Review
1992
Review
1992
Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs.
A variety of recently developed drugs, designed to be used in antifilarial chemotherapy, contain a thiocarbonylamide group as a… Expand
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1991
1991
Onchocercacidal effects of amocarzine (CGP 6140) in Latin America
An open clinical trial of amocarzine was carried out in onchocerciasis patients in Ecuador and Guatemala. Administration after… Expand
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1991
1991
Onchocercacidal effect of three drug regimens of amocarzine in 148 patients of two races and both sexes from Esmeraldas, Ecuador.
The objective of this multidisciplinary clinical investigation was to test whether amocarzine was absorbed effectively and safely… Expand
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1991
1991
Use of an ophthalmologic ultrasoundscanner in human onchocercal skin nodules for non-invasive sequential assessment during a macrofilaricidal trial with amocarzine in Guatemala. The first experiences…
Ultrasonography of onchocercal skin nodules was performed with an ophthalmologic real time linear scanner with a B probe of 10… Expand
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