FAQ

aminocarboxymuconate-semialdehyde decarboxylase activity

Known as: 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming), alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity, 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity 
Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). [EC:4.1.1.45, RHEA:16560]

Topic mentions per year

Topic mentions per year

1981-2016
01219812016

Papers overview

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2016
2016
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation
Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is… (More)
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2009
2009
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and…
The enzyme alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a zinc-dependent amidohydrolase that… (More)
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2006
2006
Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.
We investigated the change of tryptophan-niacin metabolism in rats with puromycin aminonucleoside PAN-induced nephrosis, the… (More)
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2006
2006
Regulation of Mouse Hepatic -Amino- -Carboxymuconate- - Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4 and…
Nicotinamide adenine dinucleotide (NAD) plays a critical role in the maintenance of cellular energy homeostasis… (More)
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2005
2005
The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.
BACKGROUND Quinolinic acid and other kynurenine metabolites of the oxidative metabolism of tryptophan play an important role in… (More)
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2004
2004
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.
Hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD; formerly termed picolinic carboxylase) [EC4.1… (More)
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2002
2002
Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes.
In the tryptophan-niacin conversion, 2-amino-3-carboxymuconate-6-semiardehyde decarboxylase (ACMSD; formerly termed picolinic… (More)
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2002
2002
Growth-promoting activity of pyrazinoic acid, a putative active compound of antituberculosis drug pyrazinamide, in niacin-deficient rats through the inhibition of ACMSD activity.
We have recently reported that the antituberculosis drug, pyrazinamide (PZA), caused a significant increase in the conversion… (More)
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2002
2002
Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.
2-Amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD; EC 4.1.1.45) is one of the important enzymes regulating tryptophan… (More)
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1985
1985
Suppressive effect of dietary unsaturated fatty acids on alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme of tryptophan-niacin metabolism in rat liver.
The effect of dietary fat on the activity of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase [EC 4… (More)
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