alpha-ketoglutarate

Known as: Alpha Ketoglutarate, alpha-oxoglutarate, 2-ketoglutarate 
 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In… (More)
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… (More)
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Highly Cited
2007
Highly Cited
2007
Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are components of the tricarboxylic acid (TCA) cycle and tumor… (More)
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Highly Cited
2005
Highly Cited
2005
Mycobacterium tuberculosis (Mtb) has adapted its metabolism for persistence in the human macrophage. The adaptations are likely… (More)
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Highly Cited
2004
Highly Cited
2004
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused by a multitude of pathological… (More)
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Highly Cited
2004
Highly Cited
2004
Alpha-ketoglutarate dehydrogenase (alpha-KGDH), a key enzyme in the Krebs' cycle, is a crucial early target of oxidative stress… (More)
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Highly Cited
2000
Highly Cited
2000
In this study we addressed the function of the Krebs cycle to determine which enzyme(s) limits the availability of reduced… (More)
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Highly Cited
1993
Highly Cited
1993
The Alcaligenes eutrophus 2,4-dichlorophenoxyacetate/alpha-ketoglutarate dioxygenase, encoded by the tfdA gene of plasmid pJP4… (More)
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Highly Cited
1993
Highly Cited
1993
The Alcaligenes eutrophus JMP134 tfdA gene, encoding the enzyme responsible for the first step in 2,4-dichlorophenoxyacetic acid… (More)
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Highly Cited
1986
Highly Cited
1986
The substrate and cofactor requirements and some kinetic properties of the alpha-ketoglutarate dehydrogenase complex (KGDHC; EC 1… (More)
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