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alpha-ketoglutarate

Known as: Alpha Ketoglutarate, alpha-oxoglutarate, 2-ketoglutarate 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… Expand
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Highly Cited
2009
Highly Cited
2009
Methylation Mediation Methylation of cytosine bases, 5-methylcytosine (5mC), in DNA plays an important regulatory role in… Expand
Highly Cited
2009
Highly Cited
2009
Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) occur in certain human brain tumors, but their… Expand
Highly Cited
2007
Highly Cited
2007
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show… Expand
Review
2005
Review
2005
Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the… Expand
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Review
2004
Review
2004
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode… Expand
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Highly Cited
2004
Highly Cited
2004
Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell death caused by a multitude of pathological… Expand
Highly Cited
2003
Highly Cited
2003
The Fe(II)- and alpha-ketoglutarate(alphaKG)-dependent dioxygenases have roles in synthesis of collagen and sensing of oxygen in… Expand
Highly Cited
2002
Highly Cited
2002
The hypoxia-inducible factors (HIFs) 1α and 2α are key mammalian transcription factors that exhibit dramatic increases in both… Expand
Highly Cited
1968
Highly Cited
1968
Treatment of rat liver mitochondria with digitonin followed by differential centrifugation was used to resolve the… Expand
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