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alpha-fluoro-beta-alanine

Known as: 2-fluoro-beta-alanine, FBAL 
National Institutes of Health

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2 relations
analogs & derivatives

Broader (1)

beta-Alanine

Papers overview

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2007
2007
Weekday on-weekend off oral capecitabine: a phase I study of a continuous schedule better simulating protracted fluoropyrimidine therapy
BackgroundAlthough protracted intravenous 5-fluorouracil is superior to bolus regimens in terms of tumour exposure to the drug… 
2004
2004
A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients
SummaryA compartmental model of the kinetics of 5-fluorouracil (5-FU) and its catabolites in humans is proposed. This model was… 
2002
2002
Population Pharmacokinetic Analysis of the Major Metabolites of Capecitabine
Capecitabine has been developed as an orally administered tumor selective fluoropyrimidine for use in the treatment of breast and… 
1998
1998
alpha-Fluoro beta alanine in urine of workers occupationally exposed to 5 fluorouracil in a 5 fluorouracil producing factory
Because of possible harmful health effects increased attention is being paid to the occupational exposure to cytostatic drugs of… 
1994
1994
PCR with end trimming and cassette ligation: a rapid method to clone exon-intron boundaries and a 5'-upstream sequence of genomic DNA based on a cDNA sequence.
We described a method for PCR amplification of unknown flanking genomic DNA fragments. This method is a combination of PCR with… 
1992
1992
Pharmacokinetics and tissue distribution of 2-fluoro-beta-alanine in rats. Potential relevance to toxicity pattern of 5-fluorouracil.
Clinical pharmacokinetic studies in our laboratory demonstrated that 2-fluoro-beta-alanine (FBAL), the major catabolite of… 
1991
1991
Disposition and metabolism of 2-fluoro-beta-alanine conjugates of bile acids following secretion into bile.
1990
1990
2-Fluoro-beta-alanine, a previously unrecognized substrate for bile acid coenzyme A:amino acid:N-acyltransferase from human liver.
1988
1988
Direct 19f NMR spectroscopic observation of 5‐fluorouracil metabolism in the isolated perfused mouse liver model
A direct analysis of 5‐fluorouracil (FUra) metabolism in the isolated perfused mouse liver was carried out using 19F NMR… 
1988
1988
Formation of conjugates of 2-fluoro-beta-alanine and bile acids during the metabolism of 5-fluorouracil and 5-fluoro-2-deoxyuridine in the isolated perfused rat liver.
We have recently demonstrated that the major biliary metabolite of 5-fluorouracil (FUra) in cancer patients is a conjugate of the… 
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