allopurinol riboside

Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies… Expand

Pentavalent antimony has been considered to be the standard treatment for leishmaniasis, but more recently, the orally… Expand

There are no safe and effective oral drugs to treat leishmaniasis and Chagas' disease. The safety, pharmacokinetics, and… Expand

Eighteen patients received 1,250 mg of allopurinol riboside (AR) four times daily for 28 d. Nine of the patients concurrently… Expand

Previous investigations have suggested that inosine analogs would be good models for the development of chemotherapeutic agents… Expand

A number of 3,4-disubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides were synthesized and tested for their biological activity… Expand

In animals and in humans given high doses of allopurinol, the oxidation of allopurinol to oxipurinol is inhibited, resulting in a… Expand

HPP-Rib is a potent antileishmanial agent, which has been useful in defining new and unusual purine metabolizing pathways in… Expand

Abstract (1) Allopurinol and guanine, both separately and together, were fed over varying periods to diiferent groups of large… Expand

Abstract When allopurinol was administered to three patients with good renal function, two suffering from gout and one a… Expand