allopurinol riboside

Pentavalent antimony has been considered to be the standard treatment for leishmaniasis, but more recently, the orally… Expand

There are no safe and effective oral drugs to treat leishmaniasis and Chagas' disease. The safety, pharmacokinetics, and… Expand

Eighteen patients received 1,250 mg of allopurinol riboside (AR) four times daily for 28 d. Nine of the patients concurrently… Expand

The growth of Leishmania donovani promastigotes and mouse L cells is differentially inhibited by several inosine analogs with… Expand

A number of 3,4-disubstituted pyrazolo[3,4-d]pyrimidine ribonucleosides were synthesized and tested for their biological activity… Expand

Previous investigations have suggested that inosine analogs would be good models for the development of chemotherapeutic agents… Expand

HPP-Rib is a potent antileishmanial agent, which has been useful in defining new and unusual purine metabolizing pathways in… Expand

Abstract (1) Allopurinol and guanine, both separately and together, were fed over varying periods to diiferent groups of large… Expand

Abstract In pigs pre-fed guanine, some 33 per cent of [8-14C]guanine administered orally appeared in the urine in 24 hr… Expand

Abstract When allopurinol was administered to three patients with good renal function, two suffering from gout and one a… Expand