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aliskiren hemifumarate

Known as: Aliskiren Fumarate, Bis((2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-(1-methylethyl)nonanamide) (2E)-but-2-enedioate 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… 
National Institutes of Health

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Related topics

3 relations
Renin Inhibitors [MoA]

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Tekamlo

Broader (1)

aliskiren

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids
Estimating the solubility and solution thermodynamics parameters of aliskiren hemifumarate (AHF) in three different room… 
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2011
2011
Pharmacovigilance analysis of adverse event reports for aliskiren hemifumarate, a first-in-class direct renin inhibitor
  • A. Ali
  • Therapeutics and clinical risk management
  • 2011
  • Corpus ID: 214237
Background The purpose of this study was to examine the postmarketing safety profile of aliskiren hemifumarate, a first-in-class… 
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2009
2009
Inhibition of Monoamine Oxidases Desensitizes 5-HT1A Autoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization
Although nicotine is generally considered to be the main compound responsible for addictive properties of tobacco, experimental… 
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2006
2006
A Novel, Selective, and Orally Available Antagonist for CC Chemokine Receptor 3
CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3) ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13… 
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2005
2005
Pharmacologic properties of YM218, a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist.
The pharmacologic profile of YM218, (Z)-4'-{4,4-difluoro-5-[2-oxo-2-(4-piperidinopiperidino)ethylidene]-2,3,4,5-tetrahydro-1H-1… 
2005
2005
Effects of YM218, a nonpeptide vasopressin V1A receptor-selective antagonist, on human vasopressin and oxytocin receptors.
The binding and signal transduction characteristics of YM218 ((Z)-4'-{4,4-difluoro-5-[2-oxo-2-(4-piperidinopiperidino)ethylidene… 
Highly Cited
2003
Highly Cited
2003
Contribution of 5-Hydroxytryptamine1B Receptors and 20-Hydroxyeiscosatetraenoic Acid to Fall in Cerebral Blood Flow After Subarachnoid Hemorrhage
Background and Purpose— This study examined the interaction between 5-hydroxytryptamine1B (5-HT1B) receptors and 20… 
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1997
1997
Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors.
We report the consequences of a 4-day treatment (b.i.d) with the 5-HT2A,2B,2C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2… 
1993
1993
Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist.
Chronic administration (twice a day for three days and on the morning of the fourth day) of SR 46349B (trans-4-[(3Z)3-(2… 
1976
1976
Comparison of the action of BD 40 A and some other beta-adrenoceptor stimulants on the isolated trachea and atria of the guinea pig.
  • H. Ida
  • Arzneimittel-Forschung
  • 1976
  • Corpus ID: 38933684
3-Formylamino-4-hydroxy-a-(N-1-methyl-2-p-methoxyphenethyl-aminomethyl)-benzylalcohol hemifumarate (BD 40A) was compared with… 
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