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aliskiren hemifumarate

Known as: Aliskiren Fumarate, Bis((2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-(1-methylethyl)nonanamide) (2E)-but-2-enedioate 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… Expand
National Institutes of Health

Papers overview

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2011
2011
  • A. Ali
  • Therapeutics and clinical risk management
  • 2011
  • Corpus ID: 214237
Background The purpose of this study was to examine the postmarketing safety profile of aliskiren hemifumarate, a first-in-class… Expand
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2011
2011
Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). To… Expand
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2009
2009
Although nicotine is generally considered to be the main compound responsible for addictive properties of tobacco, experimental… Expand
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2006
2006
CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3) ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13… Expand
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2005
2005
The pharmacologic profile of YM218, (Z)-4'-{4,4-difluoro-5-[2-oxo-2-(4-piperidinopiperidino)ethylidene]-2,3,4,5-tetrahydro-1H-1… Expand
2005
2005
The binding and signal transduction characteristics of YM218 ((Z)-4'-{4,4-difluoro-5-[2-oxo-2-(4-piperidinopiperidino)ethylidene… Expand
Highly Cited
2003
Highly Cited
2003
Background and Purpose— This study examined the interaction between 5-hydroxytryptamine1B (5-HT1B) receptors and 20… Expand
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1994
1994
The ability of SR 46349B [trans,4-([3Z)3-(2-dimethylaminoethyl)oxyimino- 3(2-flurophenyl)propen-1-yl]phenol hemifumarate], a 5… Expand
1993
1993
Chronic administration (twice a day for three days and on the morning of the fourth day) of SR 46349B (trans-4-[(3Z)3-(2… Expand
1976
1976
  • H. Ida
  • Arzneimittel-Forschung
  • 1976
  • Corpus ID: 38933684
3-Formylamino-4-hydroxy-a-(N-1-methyl-2-p-methoxyphenethyl-aminomethyl)-benzylalcohol hemifumarate (BD 40A) was compared with… Expand