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aliskiren hemifumarate

Known as: Aliskiren Fumarate, Bis((2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-(1-methylethyl)nonanamide) (2E)-but-2-enedioate 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… 
National Institutes of Health

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3 relations
Renin Inhibitors [MoA]

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Tekamlo

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aliskiren

Papers overview

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Review
2018
Review
2018
Assessing the possibilities of designing a unified multistep continuous flow synthesis platform
The multistep flow synthesis of complex molecules has gained momentum over the last few years. A wide range of reaction types and… 
2014
2014
Development and Validation of a Stability Indicating RP-HPLC Method for Simultaneous Estimation of Aliskiren Hemifumarate, Amlodipine Besylate and Hydrochlorothiazide in Bulk and Pharmaceutical…
A simple, selective and precise RP-HPLC method was developed for the simultaneous estimation of Aliskiren Hemifumarate… 
2013
2013
Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring
Recently, the discovery of the aminoisoindoles as potent and selective inhibitors of β-secretase was reported, including the… 
2006
2006
Gateways to clinical trials.
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data the… 
2001
2001
Aliskiren fumarate: Prop INNM
1999
1999
Effects of SK-951, a benzofuran derivative, as a prokinetic agent in rats and dogs.
The gastrokinetic activity of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3-dihy dro-2-methylbenzo[b… 
1999
1999
Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors.
The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo… 
1998
1998
Serotonin 5-HT4 receptor agonistic activity of the optical isomers of (+/-)-4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2-methylbenzo[b]furan-7-carboxamide.
The enantiomers, (R)-(-)-1 and (S)-(+)-1, of (+/-)-4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl)ethyl]-5-chloro-2,3- dihydro-2… 
1994
1994
Further evidence that various 5-HT receptor subtypes modulate central respiratory activity: in vitro studies with SR 46349B.
1986
1986
Studies on the receptor profile of bisoprolol.
The in vitro binding affinity of (+/-)-1-[4-(2-isopropoxyethoxymethyl)-phenoxy]-3-isopropylamino-2- propranol hemifumarate… 
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