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aliskiren hemifumarate

Known as: Aliskiren Fumarate, Bis((2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-(1-methylethyl)nonanamide) (2E)-but-2-enedioate 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… 
National Institutes of Health

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3 relations
Renin Inhibitors [MoA]

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Tekamlo

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aliskiren

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors.
Highly Cited
2014
Highly Cited
2014
Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant
Real-time control using process analytical technology (PAT) tools is required for the implementation of continuous… 
2011
2011
Pharmacovigilance analysis of adverse event reports for aliskiren hemifumarate, a first-in-class direct renin inhibitor
Background The purpose of this study was to examine the postmarketing safety profile of aliskiren hemifumarate, a first-in-class… 
2009
2009
Inhibition of Monoamine Oxidases Desensitizes 5-HT1A Autoreceptors and Allows Nicotine to Induce a Neurochemical and Behavioral Sensitization
Although nicotine is generally considered to be the main compound responsible for addictive properties of tobacco, experimental… 
Highly Cited
2006
Highly Cited
2006
A Novel, Selective, and Orally Available Antagonist for CC Chemokine Receptor 3
CC chemokine ligand 11 (CCL11/eotaxin) and other CC chemokine receptor 3 (CCR3) ligands (CCL24/eotaxin-2, CCL26/eotaxin-3, CCL13… 
2005
2005
Pharmacologic properties of YM218, a novel, potent, nonpeptide vasopressin V1A receptor-selective antagonist.
Highly Cited
2003
Highly Cited
2003
Contribution of 5-Hydroxytryptamine1B Receptors and 20-Hydroxyeiscosatetraenoic Acid to Fall in Cerebral Blood Flow After Subarachnoid Hemorrhage
Background and Purpose— This study examined the interaction between 5-hydroxytryptamine1B (5-HT1B) receptors and 20… 
1997
1997
Repeated DOI and SR 46349B treatments do not affect elevated plus-maze anxiety despite opposite effects on cortical 5-HT2A receptors.
1993
1993
Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist.
1976
1976
Comparison of the action of BD 40 A and some other beta-adrenoceptor stimulants on the isolated trachea and atria of the guinea pig.
3-Formylamino-4-hydroxy-a-(N-1-methyl-2-p-methoxyphenethyl-aminomethyl)-benzylalcohol hemifumarate (BD 40A) was compared with… 
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