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alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Papers overview

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2006
2006
Estradiol attenuates mitochondrial depolarization in polyol-stressed lens epithelial cells.
PURPOSE This study examined the state of mitochondrial physiology subsequent to exposing lens epithelium to high ambient… 
Highly Cited
2002
Highly Cited
2002
Aldose reductase activation is a key component of myocardial response to ischemia
Aldose reductase, a member of the aldo‐keto reductase family, has been implicated in the development of vascular and neurological… 
2001
2001
Modulation of aldose reductase activity through S-thiolation by physiological thiols.
1997
1997
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats.
GP-1447 {3-[(4,5,7-trifluorobenzothiazol-2-yl) methyl]-5-methylphenylacetic acid}, a novel aldose reductase (AR) inhibitor… 
1993
1993
Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction.
1992
1992
Effects of osmotic stress and hyperglycemia on aldose reductase gene expression in human renal proximal tubule cells.
1991
1991
Increased Erythrocyte Aldose Reductase Activity in Type 1 Diabetic Patients
Elevated erythrocyte sorbitol levels have been demonstrated in diabetic patients. In order to explain the enhanced sorbitol… 
1990
1990
Clinical Significance of Erythrocyte Sorbitol—Blood Glucose Ratios in Type II Diabetes Mellitus
The polyol pathway has been implicated in the pathogenesis of diabetic complications. To determine the activity of the polyol… 
Highly Cited
1989
Highly Cited
1989
Signal for induction of aldose reductase in renal medullary cells by high external NaCl.
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts… 
1980
1980
Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action.
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