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alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Papers overview

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2013
2013
Increasing evidence suggests that oxidative stress is involved in the pathogenesis of diabetic nephropathy (DN) and this can be… Expand
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2010
2010
The effects of ursolic acid on the polyol pathway and glucose homeostasis-related metabolism were examined in the livers of… Expand
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Highly Cited
2008
Highly Cited
2008
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is… Expand
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2008
2008
Purpose Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of… Expand
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2006
2006
Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world… Expand
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Highly Cited
2003
Highly Cited
2003
We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of glial fibrillary acidic protein… Expand
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2002
2002
Aldose reductase, a member of the aldo-keto reductase family, has been implicated in the development of vascular and neurological… Expand
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1994
1994
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular… Expand
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Review
1994
Review
1994
Renal medullary cells are naturally exposed to extremely high and variable interstitial concentrations of NaCl and urea… Expand
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1984
1984
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… Expand
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