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alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The effects of ursolic acid on the polyol pathway and glucose homeostasis-related metabolism were examined in the livers of… Expand
Highly Cited
2008
Highly Cited
2008
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose Activation of polyol pathway due to increased aldose reductase (ALR2) activity has been implicated in the development of… Expand
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Highly Cited
2006
Highly Cited
2006
Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world… Expand
Highly Cited
2003
Highly Cited
2003
We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of glial fibrillary acidic protein… Expand
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Review
1994
Review
1994
  • M. Burg
  • The Journal of experimental zoology
  • 1994
  • Corpus ID: 23174925
Renal medullary cells are naturally exposed to extremely high and variable interstitial concentrations of NaCl and urea… Expand
Highly Cited
1994
Highly Cited
1994
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular… Expand
Highly Cited
1991
Highly Cited
1991
Increased sorbitol levels have been demonstrated in tissues of diabetic patients. Although tissue sorbitol levels correlate with… Expand
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Highly Cited
1989
Highly Cited
1989
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts… Expand
Highly Cited
1984
Highly Cited
1984
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… Expand
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