FAQ

alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
051019682017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes.
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is… (More)
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Highly Cited
2006
Highly Cited
2006
The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity.
Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral diabetic neuropathy (PDN) have been… (More)
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2003
2003
Transgenic mice overexpressing aldose reductase in Schwann cells show more severe nerve conduction velocity deficit and oxidative stress under hyperglycemic stress.
To further understand the role of aldose reductase (AR) in the etiology of diabetic neuropathy, we generated transgenic mice that… (More)
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2002
2002
Aldose reductase activation is a key component of myocardial response to ischemia.
Aldose reductase, a member of the aldo-keto reductase family, has been implicated in the development of vascular and neurological… (More)
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Highly Cited
1999
Highly Cited
1999
Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group.
OBJECTIVE To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and nerve… (More)
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Highly Cited
1997
Highly Cited
1997
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury.
Diabetes increases the incidence of cardiovascular disease as well as the complications of myocardial infarction. Studies using… (More)
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1994
1994
Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular… (More)
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1989
1989
Aldose reductase and polyol in cultured pericytes of human retinal capillaries.
Aldose reductase has been found in several tissues involved in the various complications of long-term diabetes. Since the loss of… (More)
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1987
1987
Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.
Aldose reductase [aldehyde reductase 2; alditol:NAD(P)+ 1-oxidoreductase, EC 1.1.1.21] catalyzes conversion of glucose to… (More)
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1984
1984
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil.
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… (More)
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