alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
051019682017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is… (More)
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Highly Cited
2006
Highly Cited
2006
Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral diabetic neuropathy (PDN) have been… (More)
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2003
2003
To further understand the role of aldose reductase (AR) in the etiology of diabetic neuropathy, we generated transgenic mice that… (More)
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2002
2002
Aldose reductase, a member of the aldo-keto reductase family, has been implicated in the development of vascular and neurological… (More)
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Highly Cited
1999
Highly Cited
1999
OBJECTIVE To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and nerve… (More)
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Highly Cited
1997
Highly Cited
1997
Diabetes increases the incidence of cardiovascular disease as well as the complications of myocardial infarction. Studies using… (More)
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1994
1994
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular… (More)
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1989
1989
Aldose reductase has been found in several tissues involved in the various complications of long-term diabetes. Since the loss of… (More)
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1987
1987
Aldose reductase [aldehyde reductase 2; alditol:NAD(P)+ 1-oxidoreductase, EC 1.1.1.21] catalyzes conversion of glucose to… (More)
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1984
1984
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… (More)
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