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alditol:NADP+ 1-oxidoreductase activity
Known as:
aldehyde reductase activity
, aldose reductase activity
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health
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Highly Cited
2013
Highly Cited
2013
D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling.
S. Bhattacharya
,
Prasenjit Manna
,
R. Gachhui
,
P. Sil
Toxicology and Applied Pharmacology
2013
Corpus ID: 25699333
Highly Cited
2010
Highly Cited
2010
Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice.
S. Jang
,
Myung‐Joo Kim
,
Myung‐Sook Choi
,
E. Kwon
,
Mi-Kyung Lee
Metabolism: Clinical and Experimental
2010
Corpus ID: 30759061
Highly Cited
2008
Highly Cited
2008
Escherichia coli YqhD Exhibits Aldehyde Reductase Activity and Protects from the Harmful Effect of Lipid Peroxidation-derived Aldehydes*
J. Pérez
,
F. Arenas
,
Gonzalo A. Pradenas
,
J. M. Sandoval
,
C. Vásquez
Journal of Biological Chemistry
2008
Corpus ID: 205369050
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is…
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Highly Cited
2006
Highly Cited
2006
Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo.
A. Kato
,
Yasuko Higuchi
,
+6 authors
I. Adachi
Journal of Agricultural and Food Chemistry
2006
Corpus ID: 24400686
Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world…
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Highly Cited
2003
Highly Cited
2003
A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.
V. Asnaghi
,
C. Gerhardinger
,
T. Hoehn
,
A. Adeboje
,
M. Lorenzi
Diabetes
2003
Corpus ID: 3224240
We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of glial fibrillary acidic protein…
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Review
1994
Review
1994
Molecular basis for osmoregulation of organic osmolytes in renal medullary cells.
M. Burg
The Journal of experimental zoology
1994
Corpus ID: 23174925
Renal medullary cells are naturally exposed to extremely high and variable interstitial concentrations of NaCl and urea…
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Highly Cited
1994
Highly Cited
1994
Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
J. Cunningham
,
P. Mearkle
,
R. G. Brown
Journal of the American College of Nutrition
1994
Corpus ID: 38434067
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular…
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Highly Cited
1991
Highly Cited
1991
Crucial Role of Aldose Reductase Activity and Plasma Glucose Level in Sorbitol Accumulation in Erythrocytes From Diabetic Patients
Y. Hamada
,
Ryuzo Kitoh
,
P. Raskin
Diabetes
1991
Corpus ID: 39828506
Increased sorbitol levels have been demonstrated in tissues of diabetic patients. Although tissue sorbitol levels correlate with…
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Highly Cited
1989
Highly Cited
1989
Signal for induction of aldose reductase in renal medullary cells by high external NaCl.
S. Uchida
,
A. García-Pérez
,
H. Murphy
,
M. Burg
American Journal of Physiology
1989
Corpus ID: 12092550
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts…
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Highly Cited
1984
Highly Cited
1984
Glomerular Polyol Accumulation in Diabetes and its Prevention by Oral Sorbinil
A. Beyer-Mears
,
L. Ku
,
M. Cohen
Diabetes
1984
Corpus ID: 38251013
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes…
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