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alditol:NADP+ 1-oxidoreductase activity

Known as: aldehyde reductase activity, aldose reductase activity 
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-κB and PKC signaling.
Highly Cited
2010
Highly Cited
2010
Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice.
Highly Cited
2008
Highly Cited
2008
Escherichia coli YqhD Exhibits Aldehyde Reductase Activity and Protects from the Harmful Effect of Lipid Peroxidation-derived Aldehydes*
Evidence that Escherichia coli YqhD is involved in bacterial response to compounds that generate membrane lipid peroxidation is… 
Highly Cited
2006
Highly Cited
2006
Inhibitory effects of Zingiber officinale Roscoe derived components on aldose reductase activity in vitro and in vivo.
Ginger (Zingiber officinale Roscoe) continues to be used as an important cooking spice and herbal medicine around the world… 
Highly Cited
2003
Highly Cited
2003
A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.
We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of glial fibrillary acidic protein… 
Review
1994
Review
1994
Molecular basis for osmoregulation of organic osmolytes in renal medullary cells.
  • M. Burg
  • The Journal of experimental zoology
  • 1994
  • Corpus ID: 23174925
Renal medullary cells are naturally exposed to extremely high and variable interstitial concentrations of NaCl and urea… 
Highly Cited
1994
Highly Cited
1994
Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
OBJECTIVE Diabetic hyperglycemia promotes sorbitol production from glucose via aldose reductase. Since the intracellular… 
Highly Cited
1991
Highly Cited
1991
Crucial Role of Aldose Reductase Activity and Plasma Glucose Level in Sorbitol Accumulation in Erythrocytes From Diabetic Patients
Increased sorbitol levels have been demonstrated in tissues of diabetic patients. Although tissue sorbitol levels correlate with… 
Highly Cited
1989
Highly Cited
1989
Signal for induction of aldose reductase in renal medullary cells by high external NaCl.
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts… 
Highly Cited
1984
Highly Cited
1984
Glomerular Polyol Accumulation in Diabetes and its Prevention by Oral Sorbinil
Although enhanced activity of the polyol pathway has been implicated in the pathogenesis of certain complications of diabetes… 
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