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alditol:NADP+ 1-oxidoreductase activity
Known as:
aldehyde reductase activity
, aldose reductase activity
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. [EC:1.1.1.21]
National Institutes of Health
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2006
2006
Estradiol attenuates mitochondrial depolarization in polyol-stressed lens epithelial cells.
J. Flynn
,
P. Cammarata
Molecular Vision
2006
Corpus ID: 32696925
PURPOSE This study examined the state of mitochondrial physiology subsequent to exposing lens epithelium to high ambient…
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Highly Cited
2002
Highly Cited
2002
Aldose reductase activation is a key component of myocardial response to ischemia
Y. Hwang
,
Sanai Sato
,
+5 authors
R. Ramasamy
The FASEB Journal
2002
Corpus ID: 14270628
Aldose reductase, a member of the aldo‐keto reductase family, has been implicated in the development of vascular and neurological…
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2001
2001
Modulation of aldose reductase activity through S-thiolation by physiological thiols.
M. Cappiello
,
P. Amodeo
,
+10 authors
U. Mura
Chemico-Biological Interactions
2001
Corpus ID: 25369252
1997
1997
Effects of a novel potent aldose reductase inhibitor, GP-1447, on aldose reductase activity in vitro and on diabetic neuropathy and cataract formation in rats.
N. Ashizawa
,
M. Yoshida
,
+6 authors
A. Matsuura
Japanese Journal of Pharmacology
1997
Corpus ID: 2126361
GP-1447 {3-[(4,5,7-trifluorobenzothiazol-2-yl) methyl]-5-methylphenylacetic acid}, a novel aldose reductase (AR) inhibitor…
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1993
1993
Control of sorbitol metabolism in renal inner medulla of diabetic rats: regulation by substrate, cosubstrate and products of the aldose reductase reaction.
R. Grunewald
,
I. Weber
,
E. Kinne-saffran
,
R. Kinne
Biochimica et Biophysica Acta
1993
Corpus ID: 23649249
1992
1992
Effects of osmotic stress and hyperglycemia on aldose reductase gene expression in human renal proximal tubule cells.
J. Petrash
,
M. Flath
,
D. Sens
,
J. Bylander
Biochemical and Biophysical Research…
1992
Corpus ID: 38316360
1991
1991
Increased Erythrocyte Aldose Reductase Activity in Type 1 Diabetic Patients
Y. Hamada
,
R. Kito
,
P. Raskin
Diabetic Medicine
1991
Corpus ID: 19621479
Elevated erythrocyte sorbitol levels have been demonstrated in diabetic patients. In order to explain the enhanced sorbitol…
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1990
1990
Clinical Significance of Erythrocyte Sorbitol—Blood Glucose Ratios in Type II Diabetes Mellitus
K. Aida
,
M. Tawata
,
H. Shindo
,
T. Onaya
Diabetes Care
1990
Corpus ID: 44514154
The polyol pathway has been implicated in the pathogenesis of diabetic complications. To determine the activity of the polyol…
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Highly Cited
1989
Highly Cited
1989
Signal for induction of aldose reductase in renal medullary cells by high external NaCl.
S. Uchida
,
A. García-Pérez
,
H. Murphy
,
M. Burg
American Journal of Physiology
1989
Corpus ID: 12092550
GRB-PAP1 is a continuous line of epithelial cells derived from rabbit renal inner medulla. These cells accumulate large amounts…
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1980
1980
Effects of benzodiazepines and valproic acid on brain aldehyde reductase and a proposed mechanism of anticonvulsant action.
M. Javors
,
V. Erwin
Biochemical Pharmacology
1980
Corpus ID: 26710713
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