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agouti protein

Known as: Agouti Signaling Protein [Chemical/Ingredient], Agouti Switch Protein, ASIP Protein 
A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in… 
National Institutes of Health

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ASIP geneIn BloodProcess of secretionagonists

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ASIP protein, humannonagouti protein, mouse

Papers overview

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Review
2002
Review
2002
Agouti: from mouse to man, from skin to fat.
The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. Its… 
Highly Cited
2000
Highly Cited
2000
Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related protein/melanocortin-4 receptor system.
Agouti protein and agouti-related protein (AGRP) antagonize alpha-melanocyte-stimulating hormone that binds to and activates the… 
Highly Cited
2000
Highly Cited
2000
Role of intracellular calcium in human adipocyte differentiation.
Intracellular calcium ([Ca(2+)](i)) modulates adipocyte lipid metabolism and inhibits the early stages of murine adipogenesis… 
Highly Cited
1999
Highly Cited
1999
Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
Highly Cited
1997
Highly Cited
1997
The Tree of Life: Universal and Cultural Features of Folkbiological Taxonomies and Inductions
Abstract Two parallel studies were performed with members of very different cultures—industrialized American and traditional… 
Highly Cited
1997
Highly Cited
1997
Effects of recombinant agouti-signaling protein on melanocortin action.
Mouse agouti protein is a paracrine signaling molecule that has previously been demonstrated to be an antagonist of melanocortin… 
Highly Cited
1996
Highly Cited
1996
Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity.
Mutations leading to ectopic expression of the murine agouti gene (a) result in progressive obesity. To further characterize this… 
Highly Cited
1995
Highly Cited
1995
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.
Mice that carry the lethal yellow (Ay) or viable yellow (Avy) mutation, two dominant mutations of the agouti (a) gene in mouse… 
Highly Cited
1994
Highly Cited
1994
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor
THE genetic loci agouti and extension control the relative amounts of eumelanin (brown–black) and phaeomelanin (yellow–red… 
Highly Cited
1994
Highly Cited
1994
Neomorphic agouti mutations in obese yellow mice
Several dominant mutations of the mouse agouti coat colour gene have pleiotropic effects that include obesity and a yellow coat… 
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