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aflatrem

Known as: 4H-3,15a-Epoxy-1-benzoxepino(6',7':6,7)indeno(1,2-b)indol-4-one, 9-(1,1-dimethyl-2-propenyl)-2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R-(3alpha,5balpha,7abeta,13balpha,13cbeta,15aalpha))- 
 
National Institutes of Health

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2014
2014
Comparison of Expression of Secondary Metabolite Biosynthesis Cluster Genes in Aspergillus flavus, A. parasiticus, and A. oryzae
Fifty six secondary metabolite biosynthesis gene clusters are predicted to be in the Aspergillus flavus genome. In spite of this… Expand
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Highly Cited
2010
Highly Cited
2010
Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters.
Species of Aspergillus produce a diverse array of secondary metabolites, and recent genomic analysis has predicted that these… Expand
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Highly Cited
2009
Highly Cited
2009
Identification of Two Aflatrem Biosynthesis Gene Loci in Aspergillus flavus and Metabolic Engineering of Penicillium paxilli To Elucidate Their Function
ABSTRACT Aflatrem is a potent tremorgenic toxin produced by the soil fungus Aspergillus flavus, and a member of a structurally… Expand
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Highly Cited
2008
Highly Cited
2008
Two novel aflatoxin-producing Aspergillus species from Argentinean peanuts.
Two novel species from Aspergillus section Flavi from different species of Arachis (peanuts) in Argentina are described as… Expand
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Highly Cited
2007
Highly Cited
2007
Production of cyclopiazonic acid, aflatrem, and aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation
The plant pathogenic fungus Aspergillus flavus produces several types of mycotoxins. The most well known are the carcinogenic… Expand
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2005
2005
The potent tremorgenic neurotoxins lolitrem B and aflatrem: A comparison of the tremor response in mice
Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremorgenic mycotoxin… Expand
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Highly Cited
2004
Highly Cited
2004
Indole-Diterpene Gene Cluster from Aspergillus flavus
ABSTRACT Aflatrem is a potent tremorgenic mycotoxin produced by the soil fungus Aspergillus flavus and is a member of a large… Expand
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Highly Cited
1994
Highly Cited
1994
Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels.
Tremorgenic indole alkaloids produce neurological disorders (e.g., staggers syndromes) in ruminants. The mode of action of these… Expand
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1989
1989
The tremorigen aflatrem is a positive allosteric modulator of the gamma-aminobutyric acidA receptor channel expressed in Xenopus oocytes.
Aflatrem, a mycotoxin from Aspergillus flavus, potentiates the gamma-aminobutyric acid (GABA)-induced chloride current. This… Expand
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1985
1985
Aflatrem: a tremorgenic mycotoxin with acute neurotoxic effects.
Tremorgenic mycotoxins induce neurologic symptoms ranging from mental confusion to tremors, seizures and death, and are… Expand
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